Medical research

Study reveals neural stem cells age rapidly

In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, Ph.D., demonstrates that neural stem cells—the stem cells of the nervous system—age rapidly.

Neuroscience

Society is not ready to make human brains

Stem cell research has allowed medicine to go places that were once science fiction. Using stem cells, scientists have manufactured heart cells, brain cells and other cell types that they are now transplanting into patients ...

Medical research

Putting a protein into overdrive to heal spinal cord injuries

Using genetic engineering, researchers at UT Southwestern and Indiana University have reprogrammed scar-forming cells in mouse spinal cords to create new nerve cells, spurring recovery after spinal cord injury. The findings, ...

Medications

Metoclopramide inhibits proliferation of leukemia stem cells

A research team at Inselspital, Bern University Hospital and the University of Bern has identified and tested the use of an agent that can effectively inhibit the proliferation of leukemia stem cells. Metoclopramide (MPR), ...

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Stem cell

Stem cells are cells found in most, if not all, multi-cellular organisms. They are characterized by the ability to renew themselves through mitotic cell division and differentiating into a diverse range of specialized cell types. Research in the stem cell field grew out of findings by Canadian scientists Ernest A. McCulloch and James E. Till in the 1960s. The two broad types of mammalian stem cells are: embryonic stem cells that are isolated from the inner cell mass of blastocysts, and adult stem cells that are found in adult tissues. In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing specialized cells, but also maintain the normal turnover of regenerative organs, such as blood, skin or intestinal tissues.

Stem cells can now be grown and transformed into specialized cells with characteristics consistent with cells of various tissues such as muscles or nerves through cell culture. Highly plastic adult stem cells from a variety of sources, including umbilical cord blood and bone marrow, are routinely used in medical therapies. Embryonic cell lines and autologous embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates for future therapies.

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