Treatments against hepatitis C virus have only been partially successful. A major problem is that antivirals generate drug resistance. Now Seong-Wook Lee of Dankook University, Yongin, Republic of Korea and his collaborators ...
May 30, 2013
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Platinum compounds, such as cisplatin and carboplatin, induce DNA cross-linking, prohibiting DNA synthesis and repair in rapidly dividing cells. They are first line therapeutics in the treatment of many solid tumors, but ...
Apr 15, 2013
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A research team from the Korea Advanced Institute of Science and Technology (KAIST) released their results on the structure and molecular details of the neurodegenerative disease-associated protein Ataxin-1. Mutations in ...
Mar 14, 2013
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Almost 10 years after completion of the Human Genome Project in 2003, scientists are making progress toward the next major goal in applying the genetic information in that "Book of Life" in medicine, leaders of an international ...
Jan 23, 2013
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Viruses prompt oncogenic transformation by genetically altering infected cells. Several recent studies have demonstrated that viruses alter the expression of microRNAs, non-coding RNA molecules that can block the expression ...
Jan 16, 2013
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Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice.
Jan 9, 2013
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Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive ...
Jan 9, 2013
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Gliomas are the most common form of brain tumor. They are highly aggressive and effective treatments are not currently available. The tumors contain glioma initiating cells (GICs), a population that is highly similar to neural ...
Dec 17, 2012
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A complex genetic regulatory network mediates the regeneration of adult skeletal muscles. In this issue of the Journal of Clinical Investigation, researchers at the State University of New York Downstate Medical Center in ...
Oct 1, 2012
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UCD researchers, Dr Anthony Chubb and PhD student Kevin O'Brien, working with Conway Fellow, Professor Denis Shields in the Complex Adaptive Systems Laboratory (CASL) are harnessing the donated computational power of personal ...
Sep 5, 2012
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