Medical research

Connective tissue on the wrong road—When organs start to scar

Scientists from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Medicine 3—Rheumatology and Immunology, headed by Prof. Dr. Georg Schett, have now decrypted a molecular network that could in future ...

Diseases, Conditions, Syndromes

Infinite hug mechanism may be key to lung fibrosis

Researchers have long known that fibrosis – scarred tissue and organs – is caused by a wound healing mechanism that goes awry beyond normal wound repair. Now, a group of researchers at the University of Toronto's Faculty ...

Immunology

Life-threatening lung disease averted in experimental models

Idiopathic pulmonary fibrosis (IPF) is a fatal condition that leaves lung tissue permanently scarred and leads to the decline and eventual failure of the respiratory system. For those diagnosed with the disease, treatment ...

Diseases, Conditions, Syndromes

Potential therapeutic target for lung fibrosis identified

In an article published online by Frontiers in Endocrinology, researchers at the Medical University of South Carolina (MUSC) report that they have identified a potential therapeutic target for lung fibrosis or scarring. They ...

Diseases, Conditions, Syndromes

Breakthrough for treatment of fibrotic diseases

Scientists have discovered a drug combination that could halt the progression of fibrosis—a condition believed to be responsible for almost half of all deaths—according to a study published in the journal European Urology.

Immunology

Regulatory and effector B cells control scleroderma

Systemic sclerosis (SSc, also known as scleroderma), a connective tissue disorder of autoimmune etiology, is characterized by excessive fibrosis in the skin and various internal organs. More than 90 percent of SSc patients ...

Diseases, Conditions, Syndromes

Mechanism of fibrosis development discovered

Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease of unknown origin with limited treatment options. Research suggests that the signaling molecule WNT5A plays a key role in the pathogenic process. Now, a group ...

Medical research

Rogue molecules provoke out-of-control scar tissue, strangle organs

Normal scar tissue forms to heal an internal wound and quietly retreats when the job is done. But in many common diseases—kidney, liver and lung fibrosis—the scar tissue goes rogue and strangles vital organs. These diseases ...

Diseases, Conditions, Syndromes

Metformin reverses established lung fibrosis

Researchers at the University of Alabama at Birmingham have shown—for the first time—that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism.

page 7 from 16