Immunology

Regulatory and effector B cells control scleroderma

Systemic sclerosis (SSc, also known as scleroderma), a connective tissue disorder of autoimmune etiology, is characterized by excessive fibrosis in the skin and various internal organs. More than 90 percent of SSc patients ...

Diseases, Conditions, Syndromes

Mechanism of fibrosis development discovered

Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease of unknown origin with limited treatment options. Research suggests that the signaling molecule WNT5A plays a key role in the pathogenic process. Now, a group ...

Medical research

Rogue molecules provoke out-of-control scar tissue, strangle organs

Normal scar tissue forms to heal an internal wound and quietly retreats when the job is done. But in many common diseases—kidney, liver and lung fibrosis—the scar tissue goes rogue and strangles vital organs. These diseases ...

Diseases, Conditions, Syndromes

New radiological procedure for the diagnosis of liver disease

Universitätsmedizin Berlin have successfully tested a new technology for use in the assessment of overweight adolescents with liver disease. Known as 'time-harmonic elastography' (THE), the technology enables physicians ...

Diseases, Conditions, Syndromes

Pulmonary fibrosis caused by single transcription factor

To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now shown that reduced activity of the transcription ...

Cardiology

Male triathletes may be putting their heart health at risk

Competitive male triathletes face a higher risk of a potentially harmful heart condition called myocardial fibrosis, according to research being presented next week at the annual meeting of the Radiological Society of North ...

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