The human brain consists of several intricate networks or "circuits." One such complex circuit, called the "reward circuit," is involved in reward-associated learning, a process in which nerve cell activity changes in response ...
Dec 5, 2019
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Cold Spring Harbor Laboratory scientists, with chemists and cancer biologists from Dana-Farber Cancer Institute (DFCI), have developed a new therapy that extended the survival of mice with acute myeloid leukemia.
Nov 19, 2019
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A transcription factor that aids neuron function also appears to enable a cell conversion in the prostate gland that can make an already recurrent cancer even more deadly, scientists say.
Nov 13, 2019
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Using CRISPR/Cas9 knockout screens a multi-institutional research team systematically interrogated the essentiality of more than 10,000 forkhead box protein A1 (FOXA1) and CTCF binding sites in breast and prostate cancer ...
Nov 11, 2019
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For decades, a transcription factor known as STAT3 has been a major therapeutic target in the treatment of cancer. But STAT3 has largely been considered "undruggable" due to the difficulty of developing compounds to effectively ...
Nov 11, 2019
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Researchers at Karolinska Institutet in Sweden have identified 10 tumour-specific potential drug targets for the brain tumour glioblastoma. The results are presented in the scientific journal Cell Reports.
Nov 5, 2019
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Most adults have experienced low back pain, at least temporarily. But for some, the pain is constant and debilitating.
Nov 5, 2019
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Researchers from the Icahn School of Medicine at Mount Sinai have discovered a circuit in rats that links cigarette smoking and the risk of developing type 2 diabetes, according to a study featured on the cover of the October ...
Oct 16, 2019
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B cells are white blood cells that generate antibodies against an almost unlimited number of pathogens, a capacity that is vital for any higher organism. However, establishing a diverse repertoire of pathogen recognition ...
Oct 8, 2019
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The cover for issue 54 of Oncotarget features Figure 2, "Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples," by Lu, et al.
Oct 4, 2019
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