Cardiology

Obesity negates beneficial drug effects

Blocking CETP—a protein that shuttles cholesterol and triglycerides between lipoproteins such as HDL and LDL—has been shown to improve levels of the "good" cholesterol HDL. Outcomes from clinical trials of CETP inhibitors, ...

Immunology

Pathway to resolve allergic asthma is discovered

A group of Brazilian researchers succeeded in preventing allergic asthma from progressing in experimental models by increasing the amount of a certain protein. This increase, in turn, blocked the CD4+ T lymphocytes responsible ...

Neuroscience

New transgenic model of Parkinson's illuminates disease biology

Parkinson's disease (PD) is a neurodegenerative disorder that presents clinically with abnormal movement and tremors at rest. In the brain, PD is marked by the accumulation of the protein, α-synuclein (αS), into clumps ...

Obstetrics & gynaecology

Making mice a tiny bit more human to study preterm birth

Preterm birth remains a global epidemic linked to a lifetime of potential health complications. It also is difficult to study in living creatures—especially the uniquely precise biology of preterm birth in humans.

Genetics

Researchers identify new genetic disorder

Researchers from Michigan State University College of Human Medicine and physicians from Spectrum Health have identified for the first time in a human patient a genetic disorder only previously described in animal models.

Diseases, Conditions, Syndromes

A sterile line of Aedes aegypti is developed to fight off arbovirosis

Transgenic males of Aedes aegypti with defective sperm have been created at the University of São Paulo's Biomedical Science Institute (ICB-USP) in Brazil and may be produced on a pilot scale next year. Alongside the development ...

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