Oncology & Cancer

Big data powers design of 'smart' cell therapies for cancer

Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. In two new papers, scientists at UC San Francisco and Princeton University present complementary strategies ...

Oncology & Cancer

Improved cancer immunotherapies require radical CAR overhaul

CAR-T cell therapy is a new and revolutionary weapon against cancer: T cells are isolated from the patient's blood for genetic modification and then infused back into the patient to attack cancer cells. Researchers from the ...

Oncology & Cancer

Tumors disrupt the immune system throughout the body

Cancer treatment has advanced with the advent of immunotherapies that, in some cancers, can overcome tumors' ability to evade the immune system by suppressing local immune responses. But a new study in mice by UC San Francisco ...

Oncology & Cancer

Cancer immunotherapy target helps fight solid tumors

Yvonne Chen engineers immune cells to target their most evasive enemy: cancer. New cancer immunotherapies generate immune cells that are effective killers of blood cancers, but they have a hard time with solid tumors. Chen, ...

Obstetrics & gynaecology

Designing an emergency stop switch for immunotherapies

Immunotherapy, unlike chemotherapy and radiotherapy, arms the body's immune system to attack cancer cells. In recent years, it has proven to be remarkably successful at treating leukemia, lymphoma and other liquid cancers, ...

Oncology & Cancer

Engineering the immune system to tackle glioblastoma

Each year, roughly 15,000 Americans are diagnosed with Glioblastoma Multiforme (GBM), the most common malignant primary brain tumor in adults, and also the most lethal. Surgery, radiation, and chemotherapy can help slow the ...

Oncology & Cancer

New vaccine strategy boosts T-cell therapy

A promising new way to treat some types of cancer is to program the patient's own T cells to destroy the cancerous cells. This approach, termed CAR-T cell therapy, is now used to combat some types of leukemia, but so far ...

Oncology & Cancer

Confining cell-killing treatments to tumors

Cytokines, small proteins released by immune cells to communicate with each other, have for some time been investigated as a potential cancer treatment.

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