Tumor cells are "cunning," according to Peter Yingxiao Wang. They have a nefarious way of evading the human immune responses that fight back against these cancerous invaders. Tumor cells express programmed death-ligand 1 ...
May 2, 2024
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Successful immunotherapy for cancer involves activating a person's own T cells to identify telltale proteins called antigens on the surface of a tumor and attack it. But some tumors have a trick: They hide themselves from ...
Feb 22, 2024
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While carcinogens are widely known to be perpetrators of cancer, a new study from researchers at the Mass General Cancer Center has shown that exposure to carcinogens can increase cancer cells' susceptibility to immune attack.
Oct 19, 2023
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Nine of twelve leukemia patients who received infusions of their own T cells after the cells had been genetically engineered to attack the patients' tumors responded to the therapy, which was pioneered by scientists in the ...
Dec 10, 2012
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Genetic abnormalities accrued by tumor cells lead to inappropriate production of proteins at the wrong time or place, or even the synthesis of unusual hybrid proteins not found in normal cells. Such abnormalities can serve ...
Mar 1, 2013
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Although chimeric antigen receptor (CAR) T cell therapy has shown potential in the treatment of hematological malignancies, its application in solid tumors is unsatisfactory due to the harsh physical barriers and immunosuppressive ...
Mar 15, 2023
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Chimeric antigen receptor (CAR) T–cell immunotherapy re-engineers a patient's immune cells to target cancer cells. While successful in some types of leukemia, the approach has yet to realize its potential against pediatric ...
Aug 5, 2024
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Treating prostate cancer with immunotherapy is currently difficult to do. But results from a first in-human Phase I trial using a chimeric antigen receptor (CAR) T cell therapy developed by researchers from City of Hope, ...
Jun 12, 2024
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New cancer therapies harness the immune system to fight tumors. One of the main principles behind these therapies is to find out precisely which molecules on cancer cells trigger an immune response. A team at the Technical ...
Dec 15, 2016
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Immunotherapies for cancer aim to induce the immune system to combat cancer cells more effectively. In the journal Angewandte Chemie International Edition, a Chinese research team has now described a new, modular strategy ...
Aug 23, 2023
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