Sequencing the genomes of tumor cells has revealed thousands of genetic mutations linked with cancer. However, sifting through this deluge of information to figure out which of these mutations actually drive cancer growth ...
Oct 22, 2014
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By analyzing the types of gut bacteria present around colorectal tumors, researchers have found a way to predict key genetic mutations in the tumors themselves, a method that could eventually inform the development of colorectal ...
Oct 9, 2015
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Combined treatment with two drugs targeting different points in the same growth-factor pathway delayed the development of treatment resistance in patients with BRAF-positive metastatic malignant melanoma. The results of a ...
Sep 29, 2012
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Women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations, researchers at The University of Texas MD Anderson Cancer Center and the Institute ...
Oct 11, 2011
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Scientists are on the hunt for a unique set of mutations, called "neoantigens," that let the immune system distinguish tumor cells from normal cells. Their goal is to help the immune system react to neoantigens and target ...
Sep 4, 2023
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A mouse model of glioblastoma, an aggressive type of cancer that can occur in the brain, suggests that this recalcitrant cancer originates from a pool of stem cells that can be a significant distance away from the resulting ...
Jul 22, 2020
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Melanomas tend to be "hot" or "cold—if they're hot, immunotherapy lights melanoma tumors like beacons for elimination by the immune system; but 40-50 percent of melanomas are cold, making them invisible to the immune system, ...
Apr 3, 2019
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New research from a collaborative team at Cleveland Clinic, led by Timothy Chan, MD, Ph.D., Chair of the Center for Immunotherapy and Precision Immuno-Oncology in the Lerner Research Institute, is demonstrating that pathogenic ...
Jul 13, 2022
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While many cells in our bodies can accumulate oncogenic mutations, the majority of these events do not lead to tumor formation as these abnormal cells are eliminated by defense mechanisms. Instead, tumors arise when a mutation ...
Nov 28, 2018
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In an effort to expand the number of cancer gene mutations that can be specifically targeted with personalized therapies, researchers at University of California San Diego School of Medicine and Moores Cancer Center looked ...
Jul 21, 2016
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