A gene regulating the F-Box and WD Repeat Domain Containing 7 (FBXW7) protein is frequently mutated or deleted in various types of human cancer, including gynecological cancers. Such FBXW7 mutations have been associated with ...
May 18, 2023
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Mutations in RAS proteins initiate many of the most aggressive tumors, and the search for pharmacological inhibitors of these proteins has become a priority in the battle against cancer. Michail Steklov, Francesca Baietti, ...
Nov 16, 2018
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The cerebral cortex is responsible for a large number of complex brain functions, ranging from the perception of sensory stimuli through alertness, memory and language to consciousness. Neurobiologists at the Max Planck Institute ...
Nov 5, 2018
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The RAF protein could be a therapeutical target to treat tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine ...
Feb 20, 2020
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Professor Yi Sun's team at the Zhejiang University report a functional compensatory effect between the Ube2m-Rbx1 and Ube2f-Sag axes of the neddylation–Cullin-RING ligases (CRLs) system in Treg cells, using conditional ...
Dec 22, 2023
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Amidst the astounding complexity of the billions of nerve cells and trillions of synaptic connections in the brain, how do nerve cells decide how far to grow or how many connections to build? How do they coordinate these ...
Jul 10, 2014
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A recent study published in Oncogene and led by Dr. Sun Yu's group at Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences revealed the roles and functional mechanisms of senescence-associated ...
Oct 25, 2022
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