Developmental changes in the brainstem driven by fragile X syndrome (FXS)—a condition that often co-occurs with autism spectrum disorder in humans—may underlie the hypersensitivity to sound observed in both humans and ...
Dec 26, 2017
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Researchers at Indiana University have found a previously undetected link between the gene that causes fragile X syndrome and increased tissue growth. The link could reveal a key biological mechanism behind the serious physical ...
Dec 5, 2017
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Northwestern Medicine scientists have discovered a delay in the maturation of fast-spiking neurons in the neonatal cortex of a mouse model of Fragile X syndrome, a human neurodevelopmental disorder.
Dec 5, 2017
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(HealthDay)—Allopurinol does not appear to improve exercise capacity or peripheral endothelial or coronary function in patients with cardiac syndrome X, according to a study published online Oct. 28 in Cardiovascular Therapeutics.
Nov 19, 2017
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A team of neuroscientists have developed an intervention that normalizes multiple biological functions in mice afflicted with Fragile X Syndrome (FXS). Its breakthrough centers on protein synthesis, or the building of proteins, ...
Nov 7, 2017
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New preclinical research suggests the potential utility of BPN14770, a selective PDE4D inhibitor currently under development by Tetra Discovery Partners as a prospective treatment for memory and cognitive problems associated ...
Nov 7, 2017
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In Fragile X Syndrome—the leading genetic form of intellectual disability and autism—the effects of a single defective gene ripple through a series of chemical pathways, altering signals between brain cells. It's a complex ...
Nov 3, 2017
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The protein behind fragile X syndrome acts as a genetic conductor, orchestrating a symphony of genes that help shape DNA's 3-D structure.
Sep 28, 2017
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Fragile X syndrome—the most common heritable cause of autism spectrum disorder—is something of a phantom. It interferes with the production of a protein critical to synapse formation during a brief period in early development ...
Aug 25, 2017
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Two genes act as molecular midwives to the birth of neurons in adult mammals and when inactivated in mice cause symptoms of Fragile X Syndrome, a major cause of mental retardation, a new Yale University study has shown.
Aug 10, 2017
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