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Landscape of cancer genes and mutational processes in breast cancer

In a study published today in Nature, researchers describe nine new genes that drive the development of breast cancer. This takes the tally of all genes associated with breast cancer development to 40.

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Collaborative study looks for clues on hard-to-treat breast cancer

Some types of breast cancer can be successfully treated with drugs such as tamoxifen, but treatment for a type of breast cancer more common in young and black women is still limited to radiation and general chemotherapy. ...

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FDA-approved drug daclizumab makes established cancer vaccine work better

A team from the Perelman School of Medicine and the Abramson Family Cancer Research Institute at the University of Pennsylvania found that the FDA-approved drug daclizumab improved the survival of breast cancer patients taking ...

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Finnish researchers identify the cause for LGL leukemia

Researchers of the University of Helsinki, Helsinki University Central Hospital and Institute for Molecular Medicine Finland, have discovered that a mutation in the STAT3 gene is an underlying cause for LGL leukemia. Since ...

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Predicting cancer relapse: Study finds high-throughput sequencing bests flow cytometry

A study led by researchers at Fred Hutchinson Cancer Research Center has found that a next-generation, high-speed DNA-decoding technology called high-throughput sequencing can detect the earliest signs of potential relapse ...

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Researchers make promising discovery in pursuit of effective lymphoma treatments

Researchers at NYU School of Medicine have identified a target for slowing the progression of multiple myeloma by using currently available drugs.

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Study combines lapatinib with cetuximab to overcome resistance in EGFR-driven tumors

Targeted therapies have been studied for years, but recent laboratory research is providing robust clues about drugs that might work better in combination, particularly in treating cancers that have become resistant to therapy. ...

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Experimental agent may help older people with chronic leukemia

The experimental drug ibrutinib (PCI-32765) shows great promise for the treatment of elderly patients with chronic lymphocytic leukemia (CLL), according to interim findings from a clinical trial.

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Phase I study of temsirolimus, capecitabine proves safe; positive survival trend seen

A phase I clinical trial examining the safety of combining temsirolimus and capecitabine in advanced malignancies suggests the two agents can be given safely to patients. In addition, the Georgetown Lombardi Comprehensive ...

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Hormone-depleting drug shows promise against localized high-risk prostate tumors

A hormone-depleting drug approved last year for the treatment of metastatic prostate cancer can help eliminate or nearly eliminate tumors in many patients with aggressive cancers that have yet to spread beyond the prostate, ...

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Sex influences survival in esophageal cancer

(HealthDay) -- Sex is an independent prognostic factor for patients with locoregional esophageal cancer (LEC) and metastatic esophageal cancer (MEC), according to a study published online May 14 in the Journal of ...

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Revised glioblastoma classification should improve patient care

Radiation oncology researchers have revised the system used by doctors since the 1990s to determine the prognosis of people with glioblastoma, which is the most devastating of malignant brain tumors.

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Scientists discover marker to identify, attack breast cancer stem cells

Breast cancer stem cells wear a cell surface protein that is part nametag and part bull's eye, identifying them as potent tumor-generating cells and flagging their vulnerability to a drug, researchers at The University of ...

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Detecting tumour cells individually

(Medical Xpress) -- Swiss researchers have devised a method to detect mutations in tumor cells that are only present in a proportion of the cancer’s cells. The analysis reveals that cells of individual ...

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Breast cancer effectively treated with chemical found in celery

Apigenin, a natural substance found in grocery store produce aisles, shows promise as a non-toxic treatment for an aggressive form of human breast cancer, following a new study at the University of Missouri. MU researchers ...

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