Glioblastoma

Study shows why some brain cancers resist treatment

Scientists at The University of Texas MD Anderson Cancer Center may have discovered why some brain cancer patients develop resistance to standard treatments including radiation and the chemotherapy agent temozolomide.

Mar 02, 2015
popularity 5 / 5 (3) | comments 0

Dog's successful surgery sets stage for treating humans

Almost five years ago, a 7-year-old Labrador retriever was operated on using a technique eventually patented by Virginia Tech biomedical engineering faculty member Rafael Davalos. The beloved family pet suffer from a cancerous ...

Feb 19, 2015
popularity 4 / 5 (1) | comments 0

Could there be a gleevec for brain cancer?

The drug Gleevec (imatinib mesylate) is well known not only for its effectiveness against chronic myeloid leukemia (CML) and acute lymphoblastic leukemia, but also for the story behinds its development. The ...

Feb 09, 2015
popularity 3.5 / 5 (2) | comments 0

What autism can teach us about brain cancer

Applying lessons learned from autism to brain cancer, researchers at The Johns Hopkins University have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive ...

Feb 09, 2015
popularity 5 / 5 (5) | comments 10

Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans, involving glial cells and accounting for 52% of all functional tissue brain tumor cases and 20% of all intracranial tumors. Despite being the most prevalent form of primary brain tumor, GBMs occur in only 2–3 cases per 100,000 people in Europe and North America. According to the WHO classification of the tumors of the central nervous system‎, the standard name for this brain tumor is "glioblastoma"; it presents two variants: giant cell glioblastoma and gliosarcoma. Glioblastomas are also an important brain tumor in canines, and research continues to use this as a model for developing treatments in humans.

Treatment can involve chemotherapy, radiation, radiosurgery, corticosteroids, antiangiogenic therapy, surgery and experimental approaches such as gene transfer.

With the exception of the brainstem gliomas, glioblastoma has the worst prognosis of any central nervous system (CNS) malignancy, despite multimodality treatment consisting of open craniotomy with surgical resection of as much of the tumor as possible, followed by concurrent or sequential chemoradiotherapy, antiangiogenic therapy with bevacizumab, gamma knife radiosurgery, and symptomatic management with corticosteroids. Prognosis is poor, with a median survival time of approximately 14 months.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Popular antioxidant likely ineffective, study finds

The popular dietary supplement ubiquinone, also known as Coenzyme Q10, is widely believed to function as an antioxidant, protecting cells against damage from free radicals. But a new study by scientists at McGill University ...

Research suggests brain's melatonin may trigger sleep

If you walk into your local drug store and ask for a supplement to help you sleep, you might be directed to a bottle labeled "melatonin." The hormone supplement's use as a sleep aid is supported by anecdotal ...

New understanding of stroke damage may aid recovery

Stroke can lead to a wide range of problems such as depression and difficulty moving, speaking and paying attention. Scientists have thought these issues were caused by damage to the brain's "computer processors"—cells ...