A surprising form of cell-to-cell communication in glioblastoma promotes global changes in recipient cells, including aggressiveness, motility, and resistance to radiation or chemotherapy.
Jun 21, 2018
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Researchers at The University of Texas MD Anderson Cancer Center have identified a tenacious subset of immune macrophages that thwart treatment of glioblastoma with anti-PD-1 checkpoint blockade, elevating a new potential ...
Dec 23, 2019
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A large team of researchers from several institutions in the U.S. and India has created an anatomic transcriptional atlas of human glioblastoma—an aggressive form of brain cancer. In their paper published in the journal ...
Glioblastoma is the most frequent and aggressive brain cancer due to its ability to escape the immune system. However, the way in which this tumor manages to induce this immune tolerance was not known in detail. A research ...
Sep 24, 2019
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Columbia researchers have learned why some glioblastomas—the most common type of brain cancer—respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy ...
Feb 15, 2019
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Glioblastoma multiforme (GBM) is the most aggressive and common malignant type of brain tumor, accounting for 16% of all primary brain tumors. Andrea Olsen from Oslo, Norway; Zachary Harpaz from Boca Raton, Florida; and Chris ...
May 1, 2023
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A team of researchers from University Hospital Zurich and the University of Zurich, the Swiss Federal Institute of Technology and biotechnology company Philochem, has found fusing cytokines with antibodies to be an effective ...
Immune checkpoint inhibitors are important medications that boost the immune system's response against certain cancers; however, they tend to be ineffective against glioblastoma, the most deadly primary brain tumor in adults. ...
Dec 23, 2019
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Glioblastomas are complex, fast-growing malignant brain tumors that are made up of various types of cells. Even with aggressive treatment—which often includes surgery, radiation, and chemotherapy—glioblastomas are difficult ...
Mar 6, 2020
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Northwestern Medicine scientists have identified how one gene connects glioblastoma stem cell self-renewal to microglia immunosuppression in glioblastoma, according to a new study published in Nature Immunology.
Sep 27, 2023
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