Neuroscience

How synaptic vesicles accumulate glutamate

In the brain, neurons communicate via neurotransmitters, which trigger electrical signals in downstream neurons by binding and activating specific receptors. Neurotransmitters are released through the fusion of synaptic vesicles, ...

Neuroscience

How a highly unstable protein may lead to neurodegeneration

EPFL scientists have reproduced key features of pathological protein aggregates found in the brain of patients with Lou Gehrig's disease and other neurological diseases, providing insight into the underlying mechanism and ...

Medical research

Tracking early signs of Alzheimer's pathology in a mouse model

About two-thirds of the risk for Alzheimer's disease (AD) is thought to arise from genetic influences, but about a third could be influenced by environment and lifestyle, opening the door for behavioral interventions that ...

Neuroscience

A novel blood serum assay to diagnose neurodegenerative diseases

Synucleinopathies are a group of neurodegenerative diseases caused by the abnormal accumulation α-synuclein, a protein normally found in the brain and neurons. Incorrect folding of α-synuclein leads to formation of "seeds," ...

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