Journal of Clinical Investigation

Oncology & Cancer

Radiation may contribute to personalized cancer vaccine

Radiation therapy appears to increase the expression of genes with mutations that induce an immune response to malignant cells, according to preclinical research by Weill Cornell Medicine and NewYork-Presbyterian investigators. ...

Medical research

Research group identifies potential therapeutic target for lupus

A recent study published in JCI found that a neutrophil's endoplasmic reticulum, the organelle that normally makes proteins in the cell, becomes stressed in the autoimmune disorder lupus. This stress activates a molecule ...

Medical research

A new way to treat severe obesity

New research could pave the way for the treatment of early morbid familial obesity, a disease that affects four to six percent of people suffering from early severe obesity.

Medical research

Inherited immune condition reversed by random DNA change

Researchers at the Garvan Institute of Medical Research have discovered that three patients with a severe genetic immunodeficiency spontaneously repaired the harmful variants in their DNA and restored normal immune function ...

Medical research

Myeloid immune cells in the blood tied to severe COVID-19

Individual variations in how the immune system responds to SARS-CoV-2 appear to impact the severity of disease. Researchers at Karolinska Institutet in Sweden have now been able to show that patients with severe COVID-19 ...

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