Terry Fox Research Institute aims to change diagnosis and management of ovarian cancer worldwide

Ovarian cancer is the fifth-leading cause of cancer-related deaths in the Western world. One in every four women diagnosed with this form of cancer is resistant to standard first-line chemotherapy. Through TFRI, leading ovarian cancer researchers and clinicians across Canada have joined forces to develop a "made-in-Canada solution" to this global clinical problem facing cancer doctors.

The team's work will result in a new stratification system for ovarian carcinoma subtypes and will help clinicians better determine what treatment will work best for each patient. Patients who do not respond to standard therapy can be directed to clinical trials where new therapies are being validated.

"This project will change the way in which pathologists, physicians and clinicians think about ovarian cancer. It will help us to classify and sub-divide ovarian cancer into different diseases through molecular profiling. A better understanding of the disease will enable the development and delivery of more personalized care for the patient, which is both better and more efficacious," says TFRI President and Scientific Director Dr. Victor Ling.

"The program brings together expertise and resources from across the country to improve the lives of women in Canada and beyond who are diagnosed with ovarian cancer," says Dr. Stuart Edmonds, Director of the Research Portfolio at the Canadian Partnership Against Cancer, a national organization funded by Health Canada to lead the implementation of a co-ordinated cancer strategy. "This is one of several projects the Partnership is supporting with the practical goal of identifying emerging technologies that can improve the early detection and treatment of cancer and lead to better outcomes."

Momentum to form the consortium of 35 investigators came from within the ovarian cancer community. The project is headed up by three Canadian researchers at two prominent cancer care and research centres. At the University of Montreal Hospital Research Centre (CRCHUM*), molecular oncologist Dr. Anne-Marie Mes-Masson and gynecologist oncologist Dr. Diane Provencher are the principal investigators. Dr. David Huntsman, a genetic pathologist with the Ovarian Cancer Research Program at BC Cancer Agency and Vancouver Coastal Health, will co-lead the study from Vancouver.

"Ovarian cancer is a relatively rare disease that is also very complex. Today we know that it consists of several different subtypes; these are not yet well understood and we have significantly more work ahead to determine what treatment will work for patients and their specific tumour subtype," says Dr. Huntsman. "This program includes an important knowledge transfer component that will enable the results to be rapidly deployed within the Canadian pathology community and readily translated into practice."

"The women who are participating in this initiative by providing tissue samples for collection and analysis are hoping this research will accelerate the pace of discovery and validation of new biomarkers for ovarian cancer," says Dr. Provencher. "We hope to redirect women to new clinical trials and, in particular, those women who don't respond to first-line therapy."

"The team is building a unique, central scientific platform that will create a rich clinical resource for researchers to validate new biomarkers and treatments for ovarian cancer. By linking together laboratory scientists with the oncologists, surgeons and pathologists who work with the patients on the front lines, our work will be much more relevant and bear fruit that will reach patients much more quickly," says Dr. Mes-Masson. A strength of the program is the ability to link research results across multiple studies underway across the country.

Provided by Terry Fox Research Institute