Inflammation, fatigue tied to omega-3 intake after breast cancer

Inflammation, fatigue tied to omega-3 intake after breast CA

(HealthDay) -- For breast cancer survivors there may be an association between inflammation, intake of omega-3 polyunsaturated fatty acid (PUFA), and fatigue, with increased intake linked to decreased inflammation and fatigue, according to research published online March 12 in the Journal of Clinical Oncology.

Catherine M. Alfano, Ph.D., of the in Bethesda, Md., and colleagues conducted a study involving 633 breast cancer survivors who participated in the Health, Eating, Activity, and Lifestyle Study; provided blood samples 30 months after diagnosis; and completed the Piper Fatigue Scale and Short Form-36 vitality scale 39 months after diagnosis. Blood samples were analyzed for C-reactive protein (CRP) and serum amyloid A levels.

The researchers found that, as CRP increased, behavioral and sensory fatigue scale scores increased, but the association was attenuated after adjustment for comorbidity and medication use. After full adjustment, breast cancer survivors with high were 1.8-fold more likely to experience fatigue. Those who had higher intake of omega-6 compared with omega-3 had higher CRP levels and were more likely to experience fatigue (odds ratio for highest versus lowest intake, 2.6).

"If confirmed by other studies, these results point toward a future trial testing whether omega-3 PUFA supplements may reduce inflammation among and whether they may also reduce fatigue, especially , among those suffering most from this potentially debilitating condition. Considering the high prevalence of fatigue among cancer survivors, effective treatment could have a significant health impact," the authors write.

Several authors disclosed financial ties to the pharmaceutical, biotechnology, and nutritional supplement industries.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Underestimated Late Effects of Breast Cancer

Oct 27, 2006

Women who have been successfully treated for breast cancer are still not in good health for many years. In a study on more than 300 affected women, epidemiologists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, ...

Recommended for you

New breast cancer imaging method promising

7 hours ago

The new PAMmography method for imaging breast cancer developed by the University of Twente's MIRA research institute and the Medisch Spectrum Twente hospital appears to be a promising new method that could ...

Palliation is rarely a topic in studies on advanced cancer

7 hours ago

End-of-life aspects, the corresponding terminology, and the relevance of palliation in advanced cancer are often not considered in publications on randomized controlled trials (RCTs). This is the result of an analysis by ...

User comments