New treatment offers benefit for hypoxic laryngeal tumors
(HealthDay) -- For patients with squamous cell laryngeal cancer, regional control rates are improved with accelerated radiotherapy (AR) plus carbogen inhalation and nicotinamide (ARCON) treatment compared with AR-alone, with the improvement seen in patients with hypoxic tumors, according to research published online April 16 in the Journal of Clinical Oncology.
Geert O. Janssens, M.D., of the Radboud University Nijmegen Medical Centre in the Netherlands, and colleagues conducted a phase 3 randomized study involving 345 patients with cT2-4 squamous cell laryngeal cancer who were treated with either AR, which consisted of 68 Gy within 36 to 38 days, or ARCON, which included 64 Gy on the laryngeal cartilage. In a side study, the oxygenation status was assessed in tumor biopsies using pimonidazole.
After a median follow-up of 44 months, the researchers found that the local tumor control rate was similar for AR and ARCON (78 and 79 percent, respectively; P = 0.80), with similar larynx preservation rates (84 and 87 percent, respectively; P = 0.48). However, the secondary end point, five-year regional control, was significantly better with ARCON versus AR (93 versus 86 percent; P = 0.04). Improved regional control was only observed in patients with hypoxic, not well-oxygenated, tumors. No difference in treatment-related toxicity between the AR and ARCON regimens was observed.
"The use of ARCON in stage II to IV laryngeal cancer produced a significant gain in regional control rate compared with AR, with similar acute and late toxicity," the authors write. "Proper patient selection based on tumor biology is key to the success of this approach."
More information: Abstract
Full Text (subscription or payment may be required)
Editorial
Journal reference:
Journal of Clinical Oncology
Copyright © 2012 HealthDay. All rights reserved.
-
Researchers discover that same gene has opposite effects in prostate, breast cancers
Oct 17, 2011 |
not rated yet |
0
-
What Is The Best Strategy For Overcoming Constant Worries?
Apr 07, 2009 |
not rated yet |
0
-
A potential new target for treatment of hormone refractory prostate cancer
Apr 06, 2009 |
not rated yet |
0
-
Study identifies new prostate cancer drug target
Feb 06, 2012 |
not rated yet |
0
-
Bevacizumab doesn't up overall survival in prostate cancer
Mar 27, 2012 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
How can there be a term called "intestinal metaplasia" of stomach
18 hours ago
-
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013
-
If you became brain-dead, would you want them to pull the plug?
May 17, 2013
-
MRI bill question
May 15, 2013
-
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013
-
Alcohol and acetaminophen
May 13, 2013
- More from Physics Forums - Medical Sciences
More news stories
Small cancer risk following CT scans in childhood and adolescence confirmed
The gap between life expectancy in patients with a mental illness and the general population has widened since 1985 and efforts to reduce this gap should focus on improving physical health, suggest researchers in a paper ...
Cancer
6 hours ago |
not rated yet |
0
Changing cancer's environment to halt its spread
By studying the roles two proteins, thrombospondin-1 and prosaposin, play in discouraging cancer metastasis, a trans-Atlantic research team has identified a five-amino acid fragment of prosaposin that significantly reduces ...
Cancer
7 hours ago |
not rated yet |
0
Novel RNA-based classification system for colorectal cancer
A novel transcriptome-based classification of colon cancer that improves the current disease stratification based on clinicopathological variables and common DNA markers is presented in a study published in PLOS Medicine this w ...
Cancer
8 hours ago |
not rated yet |
0
Low radiation scans help identify cancer in earliest stages
A study of veterans at high risk for developing lung cancer shows that low-dose computed tomography (LDCT) can be highly effective in helping clinicians spot tiny lung nodules which, in a small number of patients, may indicate ...
Cancer
9 hours ago |
not rated yet |
0
Poliovirus vaccine trial shows early promise for recurrent glioblastoma
An attack on glioblastoma brain tumor cells that uses a modified poliovirus is showing encouraging results in an early study to establish the proper dose level, researchers at Duke Cancer Institute report.
Cancer
11 hours ago |
not rated yet |
0
If you can remember it, you can remember it wrong
(Medical Xpress)—Native peoples in regions where cameras are uncommon sometimes react with caution when their picture is taken. The fear that something must have been stolen from them to create the photo ...
B vitamins could delay dementia
(Medical Xpress)—Despite spending billions of dollars on research and development, drug companies have been unable to come up with effective treatments for dementia and Alzheimer's Disease (AD). Now, A. ...
New sleeping pill poised to hit US markets
An experimental sleeping pill from US drug company Merck is effective at helping people fall and stay asleep, according to reviewers at the US Food and Drug Administration, which could soon approve the new drug.
Reducing caloric intake delays nerve cell loss
Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice, according to a study published in the May ...
Insight into the dazzling impact of insulin in cells
Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.
Antidepressant reduces stress-induced heart condition
A drug commonly used to treat depression and anxiety may improve a stress-related heart condition in people with stable coronary heart disease, according to researchers at Duke Medicine.
