Important study on adrenal cortex cancer completed
(Medical Xpress) -- Adrenocortical cancer is an uncommon form of cancer that is often fatal. For the first time, a large-scale randomized treatment study has now been carried out. The study is being published in the prestigious New England Journal of Medicine and constitutes an important and long-awaited platform for continued research.
This is a major international collaboration and an entirely academic study, with no funding from drug companies. Its important for both patients and their physicians to evaluate treatment alternatives, says Britt Skogseid, professor of tumour endocrinology at Uppsala University, who directed the study and has received many favourable reactions to the Swedish initiative from all over the world.
The chance of surviving advanced adrenal gland cancer is low, less than 15 per cent. Because the disease is uncommon, 0.7-2 cases per million, it is impossible for a single country to amass a sufficiently large patient base. In this phase-III study researchers compared the outcome of the two most widely used chemotherapy treatments, both in combination with mitotan.
With 12 countries working in collaboration, a robust study has now been carried out, covering 304 patients with metastasized adrenocortical cancer. The NIH in the US also provided patients for the study. One group was given mitotan in combination with etoposide, doxorubicin and cisplatin every fourth week, while the other group was given mitotan in combination with streptozotocin every third week. In cases of treatment failure, patients were given the alternative treatment.
The results show that the former combination had an effect on the tumour in 23.2 per cent of cases, while the latter combination was effective in 9.2 per cent of cases. The former drug combination also led to a longer period of zero tumour growth. On the other hand, there was no difference in mortality. In most patients the tumour continued to grow, and the survival rate was only 24 per cent at the end of the study.
Until now we physicians have had to deal with this serious disease without being able to lean on the findings of controlled studies. There is still no good treatment, but at least we now have something to relate to, and we have a network of researchers all over the world for future studies, says Britt Skogseid.
More information: Reference: N Engl J Med 2012; 366:2189-2197June 7, 2012. www.nejm.org/doi/f… oa1200966%20
Journal reference: New England Journal of Medicine
Provided by Uppsala University
- Combination chemotherapy shows benefits for adrenal cancer patients May 04, 2012 | not rated yet | 0
- Gene fault could predict ovarian cancer drug success Jun 06, 2011 | not rated yet | 0
- Diabetes treatment doubles skin cancer drug's effectiveness Apr 02, 2012 | not rated yet | 0
- A giant little step in cancer treatment opening up new therapeutic horizons Feb 27, 2012 | not rated yet | 0
- Treatment of common virus can reduce tumour growth Sep 27, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
How can there be villous adenoma in colon, if there are no villi there
12 hours ago As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
- More from Physics Forums - Medical Sciences
More news stories
(HealthDay)—The American Cancer Society, which is celebrating on Wednesday a century of fighting a disease once viewed as a death sentence, is making a pledge to put itself out of business.
Cancer 1 hour ago | not rated yet | 0
National Lung Screening Trial (NLST) investigators also conclude that the 20 percent reduction in lung cancer mortality with low-dose computed tomography (LDCT) versus chest X-ray (CXR) screening previously reported in the ...
Cancer 2 hours ago | not rated yet | 0
Researchers have developed a new drug delivery system that allows inhalation of chemotherapeutic drugs to help treat lung cancer, and in laboratory and animal tests it appears to reduce the systemic damage ...
Cancer 5 hours ago | not rated yet | 0 |
When turned on, the gene p53 turns off cancer. However, when existing drugs boost p53, only a few tumors die – the rest resist the challenge. A study published in the journal Cell Reports shows how: tumors that live even i ...
Cancer 5 hours ago | not rated yet | 0 |
Study leader, Professor John Mathews from the University of Melbourne said this small increase in cancer risk must be weighed against the undoubted benefits from CT scans in diagnosing and monitoring disease.
Cancer 9 hours ago | not rated yet | 0
(HealthDay)—For HIV-infected individuals with recurrent Clostridium difficile infection, fecal microbiota therapy is feasible, according to a letter published in the May 21 issue of the Annals of Intern ...
57 minutes ago | not rated yet | 0
Calorie information in fast food restaurants used by 40 percent of 9-18 year olds when making food choices
A new study published online today (Thursday) in the Journal of Public Health has found that of young people who visited fast food or chain restaurants in the U.S. in 2010, girls and youth who were obese were more likely ...
2 minutes ago | not rated yet | 0
(HealthDay)—Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.
2 hours ago | 5 / 5 (1) | 0 |
An independent panel of experts on Wednesday recommended US approval of a new Merck sleeping pill called suvorexant, but expressed concerns over the highest dosage and risks of drowsy daytime driving.
1 hour ago | not rated yet | 0
Until now, little was scientifically known about the human potential to cultivate compassion—the emotional state of caring for people who are suffering in a way that motivates altruistic behavior.
3 hours ago | not rated yet | 1 |