Ratio of appetite-regulating hormones marker of successful dieters
A pre-diet measurement of two hormones related to weight regulation can help predict which dieters will be more likely to maintain their weight loss and who will not, according to a new study. The results will be presented Sunday at The Endocrine Society's 94th Annual Meeting in Houston.
With obesity rates in many countries steadily climbing, more people are turning to diets to lose weight. But, for many people, maintaining the weight loss can be extremely difficult, leading to a frustrating cycle of weight loss and gain.
"The current study shows for the first time a clinically useful marker to identify, at an early time, patients who have difficulties in maintaining their body weight," said study author Ana B. Crujeiras , Ph.D., doctor at University Hospital of Santiago de Compostela (CHUS) and Biomedical Network Research Center in Physiopathology of obesity and Nutrition (CIBERobn) in Santiago de Compestela, Spain. "This difficulty is one of the most significant obstacles for obesity therapy, and currently there are no biological markers that effectively demonstrate clinical usefulness in predicting weight-loss regain."
To address this problem, investigators analyzed the role of two hormones related to appetite regulation. Leptin is made by the cells found in fat tissue, and ghrelin is mainly manufactured by cells in the stomach. Previous research by Crujeiras and co-investigators showed that patients who later regained weight had higher leptin and lower ghrelin levels before starting a restricted-calorie diet.
In the current study, investigators found the pre-diet leptin/ghrelin ratio to be two times higher among study participants who later regained weight than among those who did not. Additionally, they identified cut-off points, which predicted more than 60 percent of patients who would later regain 10 percent or more of the weight they initially lost.
"Calculating the leptin/ghrelin ratio prior to the participation in a weight-reduction program might provide the opportunity to individualize weight-loss therapeutic programs according to patients' needs, counteracting the weight-regain rate, and, as a consequence, achieving successful management of obesity," Crujeiras said.
Among women, the leptin/ghrelin ratio identified 70 percent of participants who later regained weight. Among men, the rate was even higher at 95 percent. Women, however, were less likely than men to be incorrectly identified as future weight gainers.
Eighty-eight overweight or obese patients, with a body mass index greater than 25, enrolled in the eight-week study. They were 44 percent female, their average age was 35 years, and all were white.
After an initial fast, participants' blood levels of leptin and ghrelin were measured. They then followed a reduced calorie diet for eight weeks. At the six-month follow-up, 40 dieters had regained the weight they had lost, while the remaining 48 had not.
Provided by The Endocrine Society
- Appetite hormones may predict weight regain after dieting Sep 09, 2010 | not rated yet | 0
- 'Yo-yo' effect of slimming diets explained Jan 12, 2011 | not rated yet | 0
- Battle of the bulge: Low leptin levels undermine successful weight loss Jun 21, 2008 | not rated yet | 0
- Bad news for insomniacs: 'hunger hormones' affected by poor sleep Mar 25, 2009 | not rated yet | 0
- Voluntary exercise by animals prevents weight gain, despite high-fat diet May 18, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Assumptions of Griffith's fracture theory
10 hours ago Any experts on Griffith's fracture theory? I am studying the subject and I am having hard time finding out if the theory is valid for all possible...
Current leading voltage or vice versa concept
11 hours ago Hello, I was wondering if there is a conceptual explanation for when current leads voltage or vice versa for capacitors or inductors with AC...
Angular Frequency of AC voltage
14 hours ago Hello, I am wondering, what is the physical interpretation of the angular frequency of AC voltage? I don't see the physicality of what the angle...
Modeling Rigid Body - Unsure about Euler angles and angular velocity
15 hours ago I'm modeling a single 3D rigid body in preparation for some more complicated modeling in order to gain a better understanding of Euler angles, the...
Function for a bullet's path
16 hours ago I've been mulling this over all weekend, and I've decided to get some help on this. The problem is writing a function to describe a bullet's path....
Elementary questions relating to Newton's laws of motion
17 hours ago i) If a wall breaks when it gets hit by a cannonball, did the wall exert an equal and opposite force on the cannonball? ii) Would the force...
- More from Physics Forums - Classical Physics
More news stories
Children who have suffered maltreatment are 36% more likely to be obese in adulthood compared to non-maltreated children, according to a new study by King's College London. The authors estimate that the prevention or effective ...
Overweight and Obesity 8 hours ago | not rated yet | 0
(Medical Xpress)—Research by the University of Leeds has shown that very young children appear to reject story book characters who are overweight, but not those who are disabled.
Overweight and Obesity May 16, 2013 | 3 / 5 (1) | 4
(HealthDay)—Weight gain in men and women is predicted by two different genetic variations—so-called polymorphisms, according to a new study from the Netherlands.
Overweight and Obesity May 15, 2013 | 5 / 5 (1) | 0 |
(HealthDay)—Drinking 500 ml of purified water is not associated with increases in resting energy expenditure (REE), according to a study presented at the annual meeting of the European Congress on Obesity, ...
Overweight and Obesity May 14, 2013 | 2 / 5 (2) | 1
(HealthDay)—Reviews that are funded by industry tend to find the evidence weak for a causal link between sugar-sweetened beverages (SSBs) and the increasing prevalence of obesity, while other reviews consider ...
Overweight and Obesity May 14, 2013 | not rated yet | 0
Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.
1 hour ago | 4.5 / 5 (2) | 0 |
The level of immunity to the recently circulating H7N9 influenza virus in an urban and rural population in Vietnam is very low, according to the first population level study to examine human immunity to the virus, which was ...
39 minutes ago | not rated yet | 0 |
Researchers at Emory University have identified a protein that stimulates a pair of "orphan receptors" found in the brain, solving a long-standing biological puzzle and possibly leading to future treatments for neurological ...
36 minutes ago | not rated yet | 0 |
Widely available in pharmacies and health stores, phosphatidylserine is a natural food supplement produced from beef, oysters, and soy. Proven to improve cognition and slow memory loss, it's a popular treatment for older ...
6 minutes ago | not rated yet | 0 |
In a striking, unexpected discovery, researchers at Albert Einstein College of Medicine of Yeshiva University have determined that vitamin C kills drug-resistant tuberculosis (TB) bacteria in laboratory culture. The finding ...
52 minutes ago | 5 / 5 (1) | 0 |
Prostaglandin analogues (PGAs), drugs which lower intraocular pressure, are often the first line of treatment for people with glaucoma, but their use is not without risks. PGAs have long been associated with blurred vision, ...
39 minutes ago | not rated yet | 0