Sleep apnea tied to insulin resistance in young, lean men

August 29, 2012
Sleep apnea tied to insulin resistance in young, lean men
In healthy, lean, young men, the presence of obstructive sleep apnea correlates with insulin resistance and compensatory hyperinsulinemia to maintain normal glucose levels, according to a study published online Aug. 21 in Diabetes Care.

(HealthDay)—In healthy, lean, young men, the presence of obstructive sleep apnea (OSA) correlates with insulin resistance and compensatory hyperinsulinemia to maintain normal glucose levels, according to a study published online Aug. 21 in Diabetes Care.

Sushmita Pamidi, M.D., from the University of Chicago, and colleagues conducted a prospective study involving healthy men (age 18 to 30 years; [BMI], 18 to 25 kg/m²) who underwent laboratory polysomnogram followed by a morning . Participants were stratified according to the presence or absence of ethnicity-based diabetes risk and family history of diabetes. Twelve men with OSA were selected and matched with 20 controls without OSA.

The researchers found that age, BMI, ethnicity-based diabetes risk, family history of diabetes, and level of exercise were similar for men with OSA and controls. Normal systolic and diastolic blood pressure and fasting lipid levels were seen in both groups. Despite having comparable glucose levels, men with OSA had 27 percent lower insulin sensitivity (estimated by Matsuda index) and 37 percent higher total , compared with control subjects, after ingestion of glucose load.

"In young, lean, and healthy men who are free of cardiometabolic disease, the presence of OSA is associated with and a compensatory rise in insulin secretion to maintain normal glucose tolerance," the authors write. "OSA may increase the risk of type 2 diabetes independently of traditional cardiometabolic risk factors."

Explore further: Liver insulin resistance correlates with cardiac risk

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Liver insulin resistance correlates with cardiac risk

April 16, 2012

(HealthDay) -- Liver insulin resistance (IR) may be a significant indicator of cardiovascular disease (CVD) risk among men, and correlates more closely with risk factors than whole-body insulin sensitivity, according to a ...

Sleep apnea severity linked to glycated hemoglobin levels

June 18, 2012

(HealthDay) -- For adults without diabetes, obstructive sleep apnea (OSA) severity is independently associated with impaired glucose metabolism, as measured by glycated hemoglobin (HbA1c) levels, according to a study published ...

Recommended for you

Unique molecular atlas of pancreas produced

September 23, 2016

Researchers at Karolinska Institutet have managed to produce the first molecular map of the genes that are active in the various cells of the human pancreas. They have also revealed differences in genetic activity between ...

Can long naps cause diabetes?

September 14, 2016

A study presented at a scientific congress Thursday reported a link between long naps and a higher risk of diabetes, though it couldn't say if daytime sleeping was a symptom or a cause.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.