Breast density does not influence breast cancer death among breast cancer patients
The risk of dying from breast cancer was not related to high mammographic breast density in breast cancer patients, according to a study published August 20 in the Journal of the National Cancer Institute.
One of the strongest risk factors for non-familial breast cancer is elevated mammographic breast density. While women with elevated mammographic breast density have a higher risk of developing breast cancer, it is not established whether a higher density indicates a lower chance of survival in breast cancer patients.
In order to determine if higher mammographic breast density is linked to a reduced survival in breast cancer patients, Gretchen L. Gierach, Ph.D., M.P.H., of the Division of Cancer Epidemiology and Genetics (DCEG) at the National Cancer Institute in Maryland, and colleagues looked at data from the U.S. Breast Cancer Surveillance Consortium and examined 9,232 women who were diagnosed with primary invasive breast carcinoma between 1996-2005 with an average follow-up of 6.6 years. The researchers studied the relationships between mammographic breast density and risk of death from breast cancer and all causes. Mammographic density was measured using the Breast Imaging Reporting and Data System (BI-RADS) density classification.
The researchers found that density does not influence the risk of death once the disease has developed. They write, "It is reassuring that elevated breast density, a prevalent and strong breast cancer risk factor, was not associated with risk of breast cancer death or death from any cause in this large, prospective study."
However, they did find an association between low density and increased risk of breast cancer death among obese patients, or those diagnosed with large or high-grade tumors. "One explanation for the increased risks associated with low density among some subgroups is that breasts with a higher percentage of fat may contribute to a tumor microenvironment that facilitates cancer growth and progression," the authors write.
They add that these findings highlight the need to further probe "possible interactions between breast density, other patient characteristics, and subsequent treatment in influencing breast cancer prognosis."
Journal reference: Journal of the National Cancer Institute
Provided by Journal of the National Cancer Institute
- Breast density linked to increased risk of subsequent breast cancer Oct 07, 2010 | not rated yet | 0
- Women born to older mothers have a higher risk of developing breast cancer Feb 06, 2012 | not rated yet | 0
- Breast density, no lobular involution increase breast cancer risk Oct 29, 2010 | not rated yet | 0
- Breast density tied to specific types of breast cancer Jul 27, 2011 | not rated yet | 0
- Breast tenderness in women getting combo hormone therapy associated with increase in breast density Oct 14, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
May 23, 2013 Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
In recent years, microRNAs (miRNAs) and other non-coding RNAs are small molecules that help control the expression of specific proteins. In recent years they have emerged as disease biomarkers. miRNA profiles have been used ...
Cancer 5 hours ago | not rated yet | 0
Cancer cells spread and grow by avoiding detection and destruction by the immune system. Stimulation of the immune system can help to eliminate cancer cells; however, there are many factors that cause the immune system to ...
Cancer 5 hours ago | not rated yet | 0
Researchers from London's Kingston University have begun a two-year study which could help prolong the lives of people with colorectal tumours.
Cancer 8 hours ago | 5 / 5 (1) | 0
Transformative research from Western University has identified new hormones in the body which may suppress breast cancer and stimulate the regression of breast tumors.
Cancer 9 hours ago | 5 / 5 (1) | 0
(Medical Xpress)—Curtin University researchers have found evidence that targeting specific cells in the body can reverse the effects of cancer on the immune system.
Cancer 9 hours ago | 5 / 5 (3) | 0
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
8 hours ago | 5 / 5 (3) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
5 hours ago | 5 / 5 (1) | 0 |
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
6 hours ago | 5 / 5 (2) | 0 |
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
3 hours ago | 5 / 5 (1) | 0 |
Talking on a hands-free device while behind the wheel can lead to a sharp increase in errors that could imperil other drivers on the road, according to new research from the University of Alberta.
2 hours ago | not rated yet | 0
(Medical Xpress)—Patients with diabetes who are depressed are much more likely to develop episodes of dangerously low blood sugars, or hypoglycemia, than are those who are not depressed, a new study has ...
9 hours ago | not rated yet | 0 |