Cetuximab, paclitaxel combo active in urothelial cancer

August 29, 2012
Cetuximab, paclitaxel combo active in urothelial cancer
The monoclonal antibody against epidermal growth factor receptor, cetuximab, augments the antitumor activity of paclitaxel in patients with previously treated urothelial cancer, according to a study published online Aug. 27 in the Journal of Clinical Oncology.

(HealthDay)—The monoclonal antibody against epidermal growth factor receptor (EGFR), cetuximab, augments the antitumor activity of paclitaxel in patients with previously treated urothelial cancer, according to a study published online Aug. 27 in the Journal of Clinical Oncology.

Yu-Ning Wong, M.D., of the Fox Chase Cancer Center in Philadelphia, and colleagues conducted a phase II, randomized, noncomparative study involving 39 patients with metastatic urothelial cancer to determine the benefits of salvage chemotherapy with cetuximab with or without paclitaxel.

In the single-agent cetuximab treatment arm, the researchers found that nine of 11 patients had progressed by eight weeks, and the arm was closed. For the 28 patients enrolled in the cetuximab plus paclitaxel arm, 12 experienced progression-free survival (PFS) longer than 16 weeks. The overall response rate was 25 percent, including three complete responses and four partial responses. The median PFS and overall survival were 16.4 and 42 weeks, respectively. Grade 3 and 4 treatment-related adverse events included rash in six patients, fatigue in five patients, and low magnesium in three cases.

"In conclusion, although cetuximab is inactive as a single agent in advanced urothelial cancer, it may augment the antitumor activity of paclitaxel when given in combination," the authors write. "The combination of paclitaxel and cetuximab should be compared with single-agent paclitaxel in a to establish the role of EGFR inhibition by in advanced urothelial cancers."

Several authors disclosed to Bristol-Myers Squibb, which funded the study and manufactures .

Explore further: High EGFR expression a predictor for improved survival with cetuximab plus chemotherapy

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Researchers thwart cancer cells by triggering 'virus alert'

August 27, 2015

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.