Colorectal cancer gene database helpful in furthering research

September 27, 2012

The CRCgene database, which gathers all genetic association studies on colorectal cancer, allows for researchers to accurately interpret the risk factors of the disease and provides insight into the direction of further colorectal cancer research, according to a study published September 27 in the Journal of the National Cancer Institute.

Approximately 950,000 new cases of colorectal cancer are diagnosed each year. The risk of developing the disease also increases with age, and as life expectancy rises, the incidence continues to grow. These factors paired with rising have made both diagnosis and treatments for the disease costly. While diet and lifestyle may affect colorectal cancer incidence, so may , and it is important to determine which genetic factors are most heavily associated with colorectal .

In order to determine the genetic factors associated with colorectal cancer, Julian Little, Ph.D., of the Department of Epidemiology and Community Medicine at the University of Ottawa and colleagues, gathered data from previously published guidelines for assessing cumulative evidence on genetic association studies, and performed meta-analyses on all the data, compiling all genetic association studies published in the field. The credibility of the studies was determined by the Venice criteria and the Bayesian False Discovery Probability (BFDP) test.

The researchers found 16 independent gene variants had the most highly credible links to colorectal cancer, with 23 variants. "The number of common, low-penetrance variants that appear to be associated with colorectal cancer is very much less than anticipated, therefore decreasing the feasibility of combining variants as a profile in a prediction tool for stratifying screening modalities on primary prevention approaches," the authors write. Still, they feel that, "the analysis here provides a resource for mining available data and puts into context the sample sizes required for the identification of true associations."

Explore further: ACP releases new colorectal cancer screening guidance statement

Related Stories

Prevalence, predictors of interval colorectal cancer ID'd

June 8, 2012

(HealthDay) -- A variety of procedural and biologic factors contribute to the development of interval colorectal cancers, seen in 7.2 percent of Medicare beneficiaries, according to a study published in the June 15 issue ...

Recommended for you

Cell phones and rats: Study explores radiation exposure

May 28, 2016

For some years research teams have explored and attempted to sort out any evidence concerning a cause-effect situation with mobile phones and cancer. Interest in the question does not disappear. Scientific groups prefer to ...

Scientists block breast cancer cells from hiding in bones

May 25, 2016

Scientists at the Duke Cancer Institute have identified a molecular key that breast cancer cells use to invade bone marrow in mice, where they may be protected from chemotherapy or hormonal therapies that could otherwise ...

Genetic sequencing reveals drug resistance growth

May 25, 2016

The rate at which genetically mutated cancer cells grow may help explain why patients with a common form of leukemia develop treatment resistance, according to new research led by a Weill Cornell Medicine investigator. The ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.