Antirheumatic drugs have minor effect on preeclampsia risk

November 6, 2012
Antirheumatic drugs have minor effect on preeclampsia risk
The use of a disease-modifying antirheumatic drug during pregnancy is rare and is associated with a nonsignificant increase in the risk for preeclampsia in women with autoimmune disease, according to a study published in the November issue of Arthritis Care & Research.

(HealthDay)—The use of a disease-modifying antirheumatic drug (DMARD) during pregnancy is rare and is associated with a nonsignificant increase in the risk for preeclampsia in women with autoimmune disease, according to a study published in the November issue of Arthritis Care & Research.

Kristin Palmsten, of the Harvard School of Public Health in Boston, and associates compared the risk for among 44,786 British Columbia women with and without , who were past users (study drug dispensing before ) and continuous users (use before and during the first 20 gestational weeks). Risks were compared for users of DMARDs, corticosteroids, and nonsteroidal anti-inflammatory drugs (NSAIDs).

The researchers found that DMARDs were dispensed to 0.1 percent of women during pregnancy. For past users, the incidence of preeclampsia was 2.3 percent for DMARDs, 2.7 percent for corticosteroids, and 2.9 percent for NSAIDs. For continuous users, compared with past users, there was a nonsignificant increase in the relative risk of preeclampsia for DMARD users. The delivery year-adjusted relative risk was 2.02 for women with systemic lupus erythematosus (SLE) compared to those without autoimmune disease. Exclusion of antimalarials attenuated the DMARD results and, on restriction of the analysis to women with autoimmune disease, the delivery-year adjusted relative risk was 0.95 (95 percent confidence interval, 0.25 to 3.55).

"We observed a two-fold increased risk of preeclampsia among women with SLE and a nonsignificant increase in risk in DMARD users," the authors write. "The DMARD and preeclampsia association was attenuated when antimalarials were excluded and null when restricted to women with autoimmune disease, which suggests the association is likely due to greater autoimmune disease severity in DMARD users."

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Women with high blood pressure during pregnancy face future of complications

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Pregnancy-related complications predict CVD in middle age

February 17, 2012

If you develop pregnancy-related hypertensive disorders or diabetes, you may have an increased risk of cardiovascular disease later in life, according to research in Circulation: Journal of the American Heart Association.

Preeclampsia poses a significant long-term health risk: study

September 4, 2012

Ben-Gurion University of the Negev (BGU) researchers have determined that preeclampsia is a significant risk factor for long-term health issues, such as chronic hypertension and hospitalizations later in life. The findings ...

Women with lupus have a higher risk for preeclampsia

October 30, 2012

New research reports that women with systemic lupus erythematosus (SLE) have a two-fold increase in risk of preeclampsia—a dangerous condition in which pregnant women develop high blood pressure (hypertension) and protein ...

Recommended for you

Zika virus may persist in the vagina days after infection

August 25, 2016

The Zika virus reproduces in the vaginal tissue of pregnant mice several days after infection, according to a study by Yale researchers. From the genitals, the virus spreads and infects the fetal brain, impairing fetal development. ...

In sub-Saharan Africa, cancer can be an infectious disease

August 26, 2016

In 1963, Irish surgeon Denis Parson Burkitt airmailed samples of an unusual jaw tumor found in Ugandan children to his colleague, Anthony Epstein, at Middlesex Hospital in London. Epstein, an expert in chicken viruses and ...

Team discovers how Zika virus causes fetal brain damage

August 24, 2016

Infection by the Zika virus diverts a key protein necessary for neural cell division in the developing human fetus, thereby causing the birth defect microcephaly, a team of Yale scientists reported Aug. 24 in the journal ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.