ASHG: 16 additional loci ID'd for coronary artery disease
Meta-analyses have identified an additional 16 loci with genome-wide significance for coronary artery disease, according to research presented at the annual meeting of the American Society of Human Genetics, held from Nov. 6 to 10 in San Francisco.
(HealthDay)—Meta-analyses have identified an additional 16 loci with genome-wide significance for coronary artery disease (CAD), according to research presented at the annual meeting of the American Society of Human Genetics, held from Nov. 6 to 10 in San Francisco.
Stavroula Kanoni, Ph.D., from the Wellcome Trust Sanger Institute in Cambridge, U.K., and colleagues conducted a two-stage meta-analysis involving 63,746 CAD cases and 130,681 controls to examine the genes associated with CAD.
The researchers found that 14 loci reached genome-wide significance. Six additional loci were examined in four independent studies, and, in a three-stage combined meta-analysis, two loci reached genome-wide significance. These results bring the number of loci for CAD to 47, with an additional 103 independent variants that correlate strongly with CAD. Together, these variants account for 10.6 percent of the heritability of CAD. Twelve of the 47 variants with genome-wide significance were significantly associated with a lipid trait, five with blood pressure, and none with diabetes. Five interaction networks were generated from network analysis of 233 candidate genes, which included 85 percent of the putative CAD genes. The four most significant pathways mapping to these networks correlated with lipid metabolism and inflammation.
"We no longer assume that coronary heart disease is triggered by just a handful of genes, each with a strong effect on a person's risk for the disease," a coauthor said in a statement. "Our research supports the current assumption that heart disease risk is determined by a large group of genes, each with a modest effect on risk."
More information: Abstract
More Information
Copyright © 2012 HealthDay. All rights reserved.
-
DNA variants explain over 10 percent of inherited genetic risk for heart disease
Nov 08, 2012 |
not rated yet |
0
-
Genetic risk factors identified for coronary artery disease, heart attack
Jan 17, 2011 |
not rated yet |
0
-
Five new genes affecting the risk of coronary artery disease identified
Sep 22, 2011 |
not rated yet |
0
-
Researchers pool data to search for genetic risks in heart disease
Oct 05, 2010 |
not rated yet |
0
-
Novel susceptibility loci identified for osteoarthritis
Jul 03, 2012 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011
- More from Physics Forums - Independent Research
More news stories
Patenting the human genome
Can human genes be patented? That was the question posed by Alan J. Snyder, vice president and associate provost for research and graduate studies at Lehigh, and Lee Kaplan, scientific director of cellular and molecular genetics ...
Genetics
4 hours ago |
4 / 5 (1) |
0
Researchers complete largest genetic sequencing study of human disease
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
Genetics
May 22, 2013 |
4.5 / 5 (4) |
0
|
Researchers develop model for better testing, targeting of malignant peripheral nerve sheath tumors
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
Genetics
May 20, 2013 |
5 / 5 (1) |
0
|
Researchers identify new circadian clock component
Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock.
Genetics
May 16, 2013 |
3 / 5 (1) |
1
|
Returning genetic incidental findings without patient consent violates basic rights, experts say
Informed consent is the backbone of patient care. Genetic testing has long required patient consent and patients have had a "right not to know" the results. However, as 21st century medicine now begins to use the tools of ...
Genetics
May 16, 2013 |
5 / 5 (1) |
3
|
Hormone levels may provide key to understanding psychological disorders in women
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
Going live: Immune cell activation in multiple sclerosis
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
ACOG: Hormone therapy not recommended to prevent CHD
(HealthDay)—Menopausal hormone therapy should not be used for prevention of coronary heart disease, according to a Committee Opinion from the American College of Obstetricians and Gynecologists (ACOG) published ...
Youth with type 2 diabetes at much higher risk for heart, kidney disease
The news about youth and diabetes keeps getting worse. The latest data from the national TODAY diabetes study shows that children who develop Type 2 diabetes are at high risk to develop heart, kidney and eye problems faster ...
New animal model gives insights into mechanisms of Parkinson's disease pathogenesis
In Parkinson's disease, the protein "alpha-synuclein" aggregates and accumulates within neurons. Specific areas of the brain become progressively affected as the disease develops and advances. The mechanism underlying this ...
Audiologists recommend smart phone apps to monitor noise levels
After studying noise in one French Quarter neighborhood of New Orleans to determine whether or not noise levels exceeded municipal ordinances, Annette Hurley, PhD, Assistant Professor of Audiology at LSU Health Sciences Center ...
