Hypertension during pregnancy increases risk of end-stage renal disease
Women with hypertensive disorders in pregnancy are at higher risk of chronic kidney disease and end-stage renal disease compared with women without the disorders, according to a study in CMAJ (Canadian Medical Association Journal).
"We found that women with hypertensive disorders during pregnancy were at higher risk of end-stage renal disease than women without complicated pregnancies," writes Dr. I-Kuan Wang, Division of Nephrology, China Medical University Hospital, Taichung, Taiwan, with coauthors.
Hypertensive disorders such as gestational hypertension and preeclampsia in pregnancy can have a major impact on the health of the mother and baby and are risk factors for death. An estimated 5% to 10% of pregnancies are affected by hypertensive disorders. Kidney function can be affected.
Researchers looked at data on 26 651 women in Taiwan with hypertensive disorders in their first pregnancy to determine whether there was an increased risk of end-stage renal disease compared with a group of 213 397 women without the disorders. The women were 19 to 40 years old and did not have a history of hypertension, diabetes or kidney disease.
Taiwan has one of the highest rates of end-stage renal disease in the world.
The incidence of chronic kidney disease was almost 11-fold higher in the group with hypertensive disorders in pregnancy compared with the women without the disorders. End-stage renal disease was 14-fold higher in the cohort with hypertensive disorders. The risk for women with preeclampsia was higher than for those with only gestational hypertension.
"We found an increased risk of subsequent end-stage renal disease among Taiwanese women who had experienced hypertensive disorders during pregnancy, including preeclampsia or eclampsia and gestational hypertension," write the authors. "We also found that women with preeclampsia or eclampsia were at higher risk of end-stage renal disease than those who had gestational hypertension only."
There is little data on the link between hypertensive disorders during pregnancy and the risk of end-stage renal disease. This study is consistent with a Norwegian study that found a similar link between these disorders and later kidney disease.
"Close surveillance for microalbuminuria, blood pressure and diabetes should be considered for women with a history of hypertensive disorders during pregnancy. Preventive strategies, such as pharmacologic or lifestyle interventions, should also be considered for women at high risk of end-stage renal disease," conclude the authors.
"This study by Wang and colleagues is timely because it shows the importance of hypertension during pregnancy as a marker for future chronic kidney disease, cardiovascular disease and diabetes," write Dr. Julia Spaan from Maastricht University Medical Center, the Netherlands, and Prof. Dr. Mark Brown from the University of New South Wales, Australia, in a related commentary (pre-embargo link only) "It also highlights one of the current pitfalls of clinical practice: although these women have great attention paid to their high blood pressure during pregnancy, there is no structured follow-up of blood pressure or cardiovascular and renal risk factors after pregnancy. Better surveillance after pregnancy should help prevent not only chronic kidney disease but also cardiovascular disease.
Journal reference: Canadian Medical Association Journal
Provided by Canadian Medical Association Journal
- Women with high blood pressure during pregnancy face future of complications Jan 29, 2009 | not rated yet | 0
- Pregnancy-related complications predict CVD in middle age Feb 17, 2012 | not rated yet | 0
- Starting to snore during pregnancy could indicate risk for high blood pressure, study says Sep 25, 2012 | not rated yet | 0
- Recurrent HTN seen for half of women with HTN in pregnancy May 18, 2012 | not rated yet | 0
- High blood pressure and pregnancy: Short- and long-term consequences Nov 11, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
No new human cases of the H7N9 virus have been recorded in China for a week, national health authorities said, for the first time since the outbreak began in March.
Diseases, Conditions, Syndromes 1 hour ago | not rated yet | 0
A Nobel prize-winning scientist Tuesday played down "shock-horror scenarios" that a new virus strain will emerge with the potential to kill millions of people.
Diseases, Conditions, Syndromes 1 hour ago | 5 / 5 (1) | 0
Bacteria resistant to the antibiotic colistin are also commonly resistant to antimicrobial substances made by the human body, according to a study in mBio, the online open-access journal of the American Society for Microb ...
Diseases, Conditions, Syndromes 6 hours ago | 5 / 5 (1) | 0
(AP)—Federal investigators probing the hantavirus outbreak blamed for three deaths at Yosemite National Park recommend that design changes to tent cabins and other lodging run by private concessionaires first be reviewed ...
Diseases, Conditions, Syndromes 12 hours ago | not rated yet | 0
A new diagnostic test for a worm infection that can lead to severe enlargement and deformities of the legs and genitals is far more sensitive than the currently used test, according to results of a field ...
Diseases, Conditions, Syndromes 13 hours ago | not rated yet | 0 |
23 minutes ago | not rated yet | 0 |
Each day, an average of nine people are killed in the United States and more than 1,000 injured by drivers doing something other than driving.
38 minutes ago | not rated yet | 0
(Medical Xpress)—We spend about a third of our life asleep, but why we need to do so remains a mystery. In a recent publication, researchers at University of Surrey and University College London suggest a new hypothesis, ...
33 minutes ago | not rated yet | 0
(Medical Xpress)—International researchers are studying the salt intake of Indian adults to provide vital new data to aid the development of a national salt reduction strategy.
23 minutes ago | not rated yet | 0
(Medical Xpress)—Exposure to sunshine as a small child is crucial to the development of a healthy eye according to results of long-term myopia study conducted by University of Sydney researchers.
13 minutes ago | not rated yet | 0
2 hours ago | not rated yet | 0 |