Ocular complications common after pediatric HSCT

Ocular complications common after pediatric HSCT
For pediatric patients undergoing hematopoietic stem cell transplantation, complications are common, but are generally mild and self-limiting, according to a study published online Feb. 28 in JAMA Ophthalmology.

(HealthDay)—For pediatric patients undergoing hematopoietic stem cell transplantation (HSCT), complications are common, but are generally mild and self-limiting, according to a study published online Feb. 28 in JAMA Ophthalmology.

To examine the development of ocular complications in children within one year after HSCT, Viera Kalinina Ayuso, M.D., from the University Medical Center Utrecht in the Netherlands, and colleagues conducted a prospective study of 49 children who underwent systematic ophthalmologic evaluations before HSCT; after the procedure and before leaving the HSCT unit; and at three, six, and 12 months after HSCT.

The researchers found that 27 percent of patients developed an ocular complication following HSCT, including dry eye syndrome (14 percent), (sub)retinal hemorrhage (12 percent), edema (6 percent), chorioretinal lesions (4 percent), vitritis (2 percent), and increased intraocular pressure (2 percent). With the exception of , which developed a median of five months after HSCT, the other conditions developed within three months after HSCT. The symptoms were mild and self-limiting in most cases. Compared to children with nonmalignant disease, children with malignant disease had an increased risk of development of ocular complications.

"In conclusion, ocular adverse effects in pediatric HSCT patients are common, but most are mild with no long-term visual sequelae; however, a potential risk of development of vision-threatening complications cannot be ruled out completely in this vulnerable group of patients," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

BMI and lean body mass decline after allogeneic HSCT

Oct 04, 2012

(HealthDay)—In survivors of childhood hematologic malignancies who have received allogeneic hematopoietic stem cell transplantation (alloHSCT), body mass index (BMI) decreases significantly, mainly due ...

Recommended for you

Looking ahead: Whole eye transplant under development

Sep 22, 2014

The concept of a whole eye transplant seems futuristic, if not impossible. But with a $1million grant from the U.S. Department of Defense, researchers at University of California, San Diego School of Medicine hope to someday ...

User comments