Study finds genetic risk factor for knee osteoarthritis

(Medical Xpress)—A newly published paper reports that individuals with radiographic knee osteoarthritis (OA) who had a specific pattern of gene variations in the interleukin-1 receptor antagonist gene (IL1RN), which is involved in controlling inflammation, were more likely to progress to severe disease than those without the gene variations.

In addition, higher , often associated with increased risk for developing severe OA, was only predictive for progression of OA in subjects who had the IL1RN gene variations.

The study was done under the direction of Dr. Joanne Jordan, director of the Thurston Arthritis Research Center at the University of North Carolina School of Medicine. "Progression of knee osteoarthritis often leads to severe disability and total knee replacement in many patients. The factors determining progression are poorly understood," said Dr. Jordan, "and the we reported appear to substantially improve our ability to identify which knee OA patients are more likely to progress. Our goal of course is to use such information to improve drug development and medical management for our OA patients."

The study was published online by the journal Osteaoarthritis and Cartilage on April 18, 2013. It evaluated radiographic progression of knee OA using data from UNC's ongoing Johnston County Osteoarthritis Project, a well characterized population in North Carolina. Of 1,153 subjects, 154 had radiographic signs of knee OA initially. If they had the specific pattern of IL1RN gene variations that is found in approximately 40 percent of Caucasians they were more than twice as likely to have radiographic progression of the disease during the 4 to 11 years monitoring period than all other individuals with knee OA.

"This study was a critical validation of the importance of IL-1 genetic variations in that we have seen in other cohorts," said Dr. Kenneth Kornman, of Interleukin Genetics and a co-author of the study. "We hope to start using this genetic information in partnerships to help guide therapeutic development to improve the management of knee OA."

More information: www.sciencedirect.com/science/… ii/S1063458413007632

add to favorites email to friend print save as pdf

Related Stories

Walking speed is a marker for knee osteoarthritis

Mar 20, 2012

(HealthDay) -- Slower walking speed may be a marker for identifying those at risk for knee osteoarthritis (OA), according to a study published online March 5 in Arthritis Care & Research.

Recommended for you

Ebola death toll passes 7,500

3 hours ago

More than 7,500 people have now died from the Ebola virus, as the number of cases climbs towards 20,000, the World Health Organization said Monday.

Ebola-infected Italian doctor 'recovering'

3 hours ago

An Italian doctor who contracted Ebola in west Africa is recovering but is still in an isolation unit, the specialist clinic in Rome treating him said Monday.

Restrictions lifted at British bird flu farm

Dec 21, 2014

Britain on Sunday lifted all restrictions at a duck farm in northern England after last month's outbreak of H5N8 bird flu, the same strain seen in recent cases across Europe.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.