New imaging technique holds promise for speeding MS research

This brain image was developed using a frequency-based MRI scan. The circled areas show lesions -- scars in the myelin. Credit: Alex Rauscher/University of British Columbia

Researchers at the University of British Columbia have developed a new magnetic resonance imaging (MRI) technique that detects the telltale signs of multiple sclerosis in finer detail than ever before – providing a more powerful tool for evaluating new treatments.

The technique analyzes the frequency of electro-magnetic waves collected by an , instead of the size of those waves. Although analyzing the number of waves per second had long been considered a more sensitive way of detecting changes in tissue structure, the math needed to create usable images had proved daunting.

Multiple sclerosis (MS) occurs when a person's attack the protective insulation, known as myelin, that surrounds . The breakdown of myelin impedes the transmitted between neurons, leading to a range of symptoms, including numbness or weakness, vision loss, tremors, dizziness and fatigue.

Alexander Rauscher, an assistant professor of radiology, and graduate student Vanessa Wiggerman in the UBC MRI Research Centre, analyzed the frequency of MRI brain scans. With Dr. Anthony Traboulsee, an associate professor of neurology and director of the UBC Hospital MS Clinic, they applied their method to 20 MS patients, who were scanned once a month for six months using both conventional MRI and the new frequency-based method.

Once scars in the myelin, known as lesions, appeared in conventional , Rauscher and his colleagues went back to earlier frequency-based images of those patients. Looking in the precise areas of those lesions, they found frequency changes – indicating tissue damage – at least two months before any sign of damage appeared on conventional scans. The results were published according to research published in the June 12, 2013, issue of Neurology, the medical journal of the American Academy of Neurology.

"This technique teases out the subtle differences in the development of MS lesions over time," Rauscher says. "Because this technique is more sensitive to those changes, researchers could use much smaller studies to determine whether a treatment – such as a new drug – is slowing or even stopping the myelin breakdown."

Related Stories

MRI research sheds new light on nerve fibers in the brain

date Nov 02, 2012

World-leading experts in Magnetic Resonance Imaging from The University of Nottingham's Sir Peter Mansfield Magnetic Resonance Centre have made a key discovery which could give the medical world a new tool for the improved ...

Recommended for you

Men and women could use different cells to process pain

date 9 hours ago

We have known for some time that there are sex differences when it comes to experiencing pain, with women showing a higher sensitivity to painful events compared to men. While we don't really understand w ...

Pupillary reflex enhanced by light inside blind spot

date 10 hours ago

University of Tokyo researchers have found that the light reflex of the pupil is modulated by light stimulation inside the blind spot in normal human observers, even though that light is not perceived.

How your brain knows it's summer

date Jun 29, 2015

Researchers led by Toru Takumi at the RIKEN Brain Science Institute in Japan have discovered a key mechanism underlying how animals keep track of the seasons. The study, published in Proceedings of the Na ...

His and her pain circuitry in the spinal cord

date Jun 29, 2015

New research released today in Nature Neuroscience reveals for the first time that pain is processed in male and female mice using different cells. These findings have far-reaching implications for our ba ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.