Review identifies risk factors for comitant strabismus

July 12, 2013
Review identifies risk factors for comitant strabismus
Risk factors for strabismus include low birth weight, prematurity, retinopathy of prematurity, smoking during pregnancy, anisometropia, hyperopia, and genetic factors, according to a review published online July 11 in JAMA Ophthalmology.

(HealthDay)—Risk factors for strabismus include low birth weight, prematurity, retinopathy of prematurity, smoking during pregnancy, anisometropia, hyperopia, and genetic factors, according to a review published online July 11 in JAMA Ophthalmology.

Gail D.E. Maconachie, B.Med.Sci., from the University of Leicester in the United Kingdom, and colleagues conducted a systematic review to identify known environmental and of comitant . Forty-one articles were included, which highlighted risk factor, twin, pedigree, and genetic studies.

The researchers identified significant risk factors for strabismus, including , cicatricial retinopathy of prematurity, prematurity, , anisometropia, hyperopia, and inheritance. Twin and pedigree studies further supported inheritance, and a complex pattern was revealed. Although various gene loci have been reported, only the STBMS1 locus has been supported.

"Certain subgroups within the population are at higher risk of developing comitant strabismus and should be identified and monitored to allow for earlier detection," the authors write. "It is evident that a strong hereditary link is present particularly in intermittent and accommodative forms; however, further research is required to identify possible links between subtypes of strabismus."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

AAP updates screening guide for retinopathy of prematurity

January 2, 2013

(HealthDay)—For the effective detection of retinopathy of prematurity (ROP), at-risk infants should receive carefully timed retinal examinations (based on their gestational age) by an ophthalmologist experienced in the ...

Recommended for you

Study points way forward for retinal disease gene therapy

May 3, 2015

Gene therapy for Leber congenital amaurosis (LCA), an inherited disorder that causes vision loss starting in childhood, improved patients' eyesight and the sensitivity of the retina within weeks of treatment. Both of these ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.