Dexamethasone beats placebo for cancer-related fatigue

Dexamethasone beats placebo for cancer-related fatigue
For patients with advanced cancer, dexamethasone is better than placebo for reducing cancer-related fatigue, according to a study published online July 29 in the Journal of Clinical Oncology.

(HealthDay)—For patients with advanced cancer, dexamethasone is better than placebo for reducing cancer-related fatigue (CRF), according to a study published online July 29 in the Journal of Clinical Oncology.

Sriram Yennurajalingam, M.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues conducted a double-blind, placebo-controlled study to compare the effect of and placebo on CRF. Patients with three or more CRF symptoms of ?4 of 10 on the Edmonton Symptom Assessment Scale (ESAS) were randomized to receive dexamethasone (43 patients) or placebo (41 patients) orally twice per day for 14 days.

The researchers found that the mean improvement in the Functional Assessment of Chronic Illness-Fatigue (FACIT-F) subscale was significantly higher in the dexamethasone group than the at day 15. The dexamethasone group also experienced a significantly greater improvement in the FACIT-F total quality-of-life scores. At day 15, the mean differences in the ESAS score were significantly better for the dexamethasone group, but there was no difference in ESAS overall symptom distress or psychological distress score. Adverse event frequency did not differ significantly between the groups.

"In conclusion, we found dexamethasone to be more effective than placebo in reducing CRF in patients with advanced cancer," the authors write. "There was a significant improvement in quality of life, physical well-being, and physical distress. Larger long-term efficacy and safety studies are needed."

One author disclosed to the pharmaceutical industry.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Prolonged dexamethasone cuts delayed nausea after chemo

date Aug 22, 2012

(HealthDay) -- Adding dexamethasone to prochlorperazine on days two and three, following palonosetron and dexamethasone on day one, reduces delayed nausea (DN) in patients receiving chemotherapy containing ...

Treatment beneficial in smoldering multiple myeloma

date Aug 01, 2013

(HealthDay)—For patients with smoldering multiple myeloma, treatment with lenalidomide plus dexamethasone correlates with delayed progression and improved survival, according to a study published in the ...

Recommended for you

Breast cancer is not one disease, experts say

date 15 hours ago

(HealthDay)—Breast cancer isn't the same for every woman, even at the cellular level, according to a new statement from four major medical groups focused on the disease.

Teens with breast lumps may be able to avoid invasive biopsy

date 17 hours ago

If a lump is found in the breast of an adolescent girl, she often will undergo an excisional biopsy. However, breast cancer is rare in adolescents, and the vast majority of teenage breast lumps turn out to be benign masses ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.