Fetal tissue-derived stem cells may be ideal source for repairing tissues and organs

Multipotent fetal dermal cells (MFDCs) may be an ideal source for cell therapy for repairing damaged tissues and organs. Their performance is superior to that of adult dermal cells, said a research team in Italy that developed a cell isolation technique for MFDCs and subsequently published a study that appears as an early e-publication for the journal Cell Transplantation.

"When compared to adult dermal cells, display several advantages, including a greater cellular yield after isolation, the ability to proliferate longer, and the retention of differentiation potential," said study co-author Dr. C.M. Chinnici of the Fondazie Ri.MED, Regenerative Medicine and Biomedical Technologies Unit in Palermo, Italy. "Cells from fetal dermis have been proven safe and efficacious in the treatment of pediatric burns, but proper characterization of these cells has not yet been provided."

Their research provided a protocol for the isolation and expansion of large numbers of MFDCs that may see future clinical use, said the study authors.

"We generated, propagated and analyzed a proliferating population of cells derived from human fetal dermis taken at 20-22 weeks of gestation," wrote the researchers. "The non-enzymatic isolation technique allows for a spontaneous selection of cells with higher motility and yields a nearly homogeneous ."

The MFDCs, they reported, were "highly proliferative and were successfully expanded with no growth factor additions." They noted that, unlike mensenchymal , which progressively lose their differentiation capacity, the MFDCs "retained their osteogenenic and adipogenic differentiation potential" meaning that their potential impact for is likely to be greater.

"The MFDCs demonstrated their favorable characteristics for a potential large scale production aimed at clinical use," said Dr. Chinnici.

The researchers noted that the most interesting aspect of their study was the finding that can be successfully isolated from small fetal skin biopsies and maintained in culture for long periods with multipotency, stability and low immunogenicity retained, "thus generating large quantities of cells for clinical use."

"Given these results, the future prospect is to translate the concept of MFDCs as cells of therapeutic interest into experimental models of tissue regeneration," they concluded.

More information: Chinnici, C. M.; Amico, G.; Monti, M.; Motta, S.; Casalone, R.; Petri, S. L.; Spada, M.; Gridelli, B.; Conaldi, P. G. Isolation and Characterization of Multipotent Cells from Human Fetal Dermis. Cell Transplant. Appeared or available online: June 13, 2013 www.ingentaconnect.com/content… rints/ct1022chinnici

add to favorites email to friend print save as pdf

Related Stories

Study finds stem cells in deer antler

Mar 19, 2013

A team of researchers in Seoul, Korea have reported finding evidence that deer antlers - unique in that they regenerate annually - contain multipotent stem cells that could be useful for tissue regeneration in veterinary ...

Human stem cell-derived hepatocytes regenerate liver function

Jul 27, 2013

Researchers have generated functional hepatocytes from human stem cells, transplanted them into mice with acute liver injury, and shown the ability of these stem-cell derived human liver cells to function normally and increase ...

Tracking nanodiamond-tagged stem cells

Aug 05, 2013

A method that is used to track the fate of a single stem cell within mouse lung tissue is reported in a study published online this week in Nature Nanotechnology. The method may offer insights into the factors that determ ...

Recommended for you

Testing time for stem cells

37 minutes ago

DefiniGEN is one of the first commercial opportunities to arise from Cambridge's expertise in stem cell research. Here, we look at some of the fundamental research that enables it to supply liver and pancreatic ...

Team finds key signaling pathway in cause of preeclampsia

19 hours ago

A team of researchers led by a Wayne State University School of Medicine associate professor of obstetrics and gynecology has published findings that provide novel insight into the cause of preeclampsia, the leading cause ...

Rapid test to diagnose severe sepsis

Oct 23, 2014

A new test, developed by University of British Columbia researchers, could help physicians predict within an hour if a patient will develop severe sepsis so they can begin treatment immediately.

User comments