Fetal tissue-derived stem cells may be ideal source for repairing tissues and organs

August 22, 2013

Multipotent fetal dermal cells (MFDCs) may be an ideal source for cell therapy for repairing damaged tissues and organs. Their performance is superior to that of adult dermal cells, said a research team in Italy that developed a cell isolation technique for MFDCs and subsequently published a study that appears as an early e-publication for the journal Cell Transplantation.

"When compared to adult dermal cells, display several advantages, including a greater cellular yield after isolation, the ability to proliferate longer, and the retention of differentiation potential," said study co-author Dr. C.M. Chinnici of the Fondazie Ri.MED, Regenerative Medicine and Biomedical Technologies Unit in Palermo, Italy. "Cells from fetal dermis have been proven safe and efficacious in the treatment of pediatric burns, but proper characterization of these cells has not yet been provided."

Their research provided a protocol for the isolation and expansion of large numbers of MFDCs that may see future clinical use, said the study authors.

"We generated, propagated and analyzed a proliferating population of cells derived from human fetal dermis taken at 20-22 weeks of gestation," wrote the researchers. "The non-enzymatic isolation technique allows for a spontaneous selection of cells with higher motility and yields a nearly homogeneous ."

The MFDCs, they reported, were "highly proliferative and were successfully expanded with no growth factor additions." They noted that, unlike mensenchymal , which progressively lose their differentiation capacity, the MFDCs "retained their osteogenenic and adipogenic differentiation potential" meaning that their potential impact for is likely to be greater.

"The MFDCs demonstrated their favorable characteristics for a potential large scale production aimed at clinical use," said Dr. Chinnici.

The researchers noted that the most interesting aspect of their study was the finding that can be successfully isolated from small fetal skin biopsies and maintained in culture for long periods with multipotency, stability and low immunogenicity retained, "thus generating large quantities of cells for clinical use."

"Given these results, the future prospect is to translate the concept of MFDCs as cells of therapeutic interest into experimental models of tissue regeneration," they concluded.

Explore further: New protocol developed to decontaminate human fetal tissues used for cell transplantation

More information: Chinnici, C. M.; Amico, G.; Monti, M.; Motta, S.; Casalone, R.; Petri, S. L.; Spada, M.; Gridelli, B.; Conaldi, P. G. Isolation and Characterization of Multipotent Cells from Human Fetal Dermis. Cell Transplant. Appeared or available online: June 13, 2013 www.ingentaconnect.com/content/cog/ct/pre-prints/ct1022chinnici

Related Stories

Tracking nanodiamond-tagged stem cells

August 5, 2013

A method that is used to track the fate of a single stem cell within mouse lung tissue is reported in a study published online this week in Nature Nanotechnology. The method may offer insights into the factors that determine ...

Recommended for you

Formaldehyde damages proteins, not just DNA

September 29, 2016

The capacity of formaldehyde, a chemical frequently used in manufactured goods such as automotive parts and wood products, to damage DNA, interfere with cell replication and cause cancer inspired new federal regulations this ...

Synthetic 3D-printed material helps bones regrow

September 28, 2016

A cheap and easy to make synthetic bone material has been shown to stimulate new bone growth when implanted in the spines of rats and a monkey's skull, researchers said Wednesday.

Epigenetic clock predicts life expectancy

September 28, 2016

UCLA geneticist Steve Horvath led a team of 65 scientists in seven countries to record age-related changes to human DNA, calculate biological age and estimate a person's lifespan. A higher biological age—regardless of chronological ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.