Spinal radiosurgery ups risk of vertebral fracture

Spinal radiosurgery ups risk of vertebral fracture

(HealthDay)—Vertebral compression fracture (VCF) is a common adverse effect in patients receiving spine stereotactic body radiotherapy (SBRT), according to research published online Aug. 19 in the Journal of Clinical Oncology.

In an effort to assess the risk and predictive factors associated with VCF, Arjun Sahgal, M.D., of the University of Toronto, and colleagues analyzed data from 252 patients with a total of 410 spinal segments treated with SBRT.

The researchers found 57 VCFs in 410 spinal segments (14 percent), which included new fractures (47 percent) and fracture progression (53 percent). About 65 percent of the fractures occurred within the first four months, and the median time to fracture was 2.46 months (range, 0.03 to 43.01 months). Risk of VCF increased with increasing dose per fraction, with the highest risk for ?24 Gy versus 20 to 23 Gy versus ?19 Gy. Three of the six criteria in the Spinal Instability Neoplastic Scoring System—baseline VCF, lytic tumor, and —were significant predictors of VCF.

"Caution must be observed when treating with ?20 Gy/fraction, in particular, for patients with lytic tumor, spinal misalignment, and a baseline VCF," the authors write. "Frequent short-term follow-up is required, as nearly two-thirds of all VCF occurred within the first four months."

Two authors disclosed to the medical technology industry.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Long wait yet for Ebola vaccine: experts

4 hours ago

It will be months, at least, before a vaccine becomes available to tackle Ebola, experts said Thursday as researchers reported success in early, safety tests with a leading candidate.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.