Depression in pregnant mothers may alter the pattern of brain development in their babies

December 4, 2013

Depression is a serious mental illness that has many negative consequences for sufferers. But depression among pregnant women may also have an impact on their developing babies.

Children of depressed parents are at an increased risk of developing depression themselves, a combination of both genetic and environmental factors. These children also display alterations in the amygdala, a brain structure important for the regulation of emotion and stress. However, prior work in this area has assessed children years after birth, which means that the timing of these alterations has remained unidentified.

Researchers led by Dr. Anqi Qiu at the National University of Singapore now have the answers, with their new work published in the current issue of Biological Psychiatry.

They set out to perform a direct analysis of prenatal and variation in the fetal development of the amygdala. To do so, they recruited 157 pregnant women who completed a depression questionnaire during their 26th week of pregnancy. Later, within two weeks of birth, newborns underwent scans to ascertain the structure of their amygdala and scans to determine the integrity of the amygdala's pattern of neural connections.

The volume of the amygdala did not differ between the infants regardless of their mothers' depression status. However, the researchers found significantly reduced structural connectivity (i.e., lower fractional anisotropy and lower axial diffusivity) in the right amygdala of infants of mothers with high levels of . In other words, the amygdala's microstructure (e.g., its "wiring") was abnormal in the infants born to depressed mothers.

This important finding suggests that a propensity for abnormal amygdala function, a feature of mood and anxiety disorders, may be transmitted from mother to child during fetal life. This finding suggests one new path that a history of maternal depression might contribute to a life-long increase in the vulnerability to .

This study provides added evidence supporting the notion that mental health screening should be included among the medical evaluations that women undergo when they discover that they are pregnant. Indeed, the authors conclude that their study supports that "interventions targeting maternal depression should begin early in pregnancy."

"Attention to maternal health during pregnancy is an extremely high priority for society for many reasons," added Dr. John Krystal, Editor of Biological Psychiatry. "The notion that maternal depression might influence the brain development of their babies is very concerning. The good news is that this risk might be reduced by systematic screening of for depression and initiating effective treatment."

More information: The article is "Prenatal Maternal Depression Associates with Microstructure of Right Amygdala in Neonates at Birth" by Anne Rifkin-Graboi, Jordan Bai, Helen Chen, Waseem Bak'r Hameed, Lit Wee Sim, Mya Thway Tint, Birit Leutscher-Broekman, Yap-Seng Chong, Peter D. Gluckman, Marielle V. Fortier, Michael J. Meaney, and Anqi Qiu (DOI: 10.1016/j.biopsych.2013.06.019). The article appears in Biological Psychiatry, Volume 74, Issue 11 (December 1, 2013)

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