Review: A-fib risk up with oral, intravenous bisphosphonates

Review: A-fib risk up with oral, intravenous bisphosphonates

(HealthDay)—The risk of atrial fibrillation is increased with use of oral or intravenous bisphosphonates, with a greater risk seen for intravenous versus oral preparations, according to a review published in the June 1 issue of The American Journal of Cardiology.

Abhishek Sharma, M.D., from the Maimonides Medical Center in Brooklyn, N.Y., and colleagues conducted a systematic literature review to examine the incidence of new-onset with use of oral and intravenous . The final analyses included five randomized controlled trials (RCTs) and four , involving 135,347 individuals.

The researchers found observed a significantly increased risk of new-onset atrial fibrillation with intravenous and oral bisphosphonates (relative risks, 1.40 and 1.22, respectively). The risk of atrial fibrillation was higher with intravenous versus oral bisphosphonates, based on the z statistic (P = 0.03).

"In conclusion, pooled data from RCTs and observational studies suggest that risk of atrial fibrillation is increased by use of oral or intravenous bisphosphonates but further suggest that risk is relatively greater with intravenous preparations," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

HRS: Bariatric surgery may prevent A-fib onset in obese

May 08, 2014

(HealthDay)—Bariatric surgery may prevent the development of atrial fibrillation in morbidly obese patients, according to research presented at the annual meeting of the Heart Rhythm Society, held from ...

Osteoporosis drug may be associated with irregular heartbeat

Apr 28, 2008

Alendronate, a medication used to prevent fractures in women with osteoporosis, may be associated with an increased risk of atrial fibrillation, a type of abnormal heart rhythm, according to a report in the April 28 issue ...

Recommended for you

Results of RIBS IV trial reported

17 hours ago

A new clinical trial comparing the use of everolimus-eluting stents (EES) and drug-eluting balloons (DEB) in treating in-stent restenosis (ISR) from drug-eluting stents found that EES provided superior late angiographic results ...

Results of DKCRUSH-VI trial reported

17 hours ago

A new study found that fractional flow reserve (FFR)-guided provisional side branch (SB) stenting of true coronary bifurcation lesions yields similar outcomes to the current standard of care. The DKCRUSH-VI clinical trial ...

Results of IVUS-CTO trial reported at TCT 2014

18 hours ago

A new study found that intravascular ultrasound (IVUS) -guided intervention in patients with chronic total occlusion (CTO) could improve outcomes compared to a conventional angiography-guided approach during percutaneous ...

Results of OCT STEMI trial reported at TCT 2014

18 hours ago

The first randomized trial to examine serial optical coherence tomography (OCT) in primary percutaneous coronary intervention (PCI) was reported at the 26th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific ...

INR variability predicts warfarin adverse effects

23 hours ago

(HealthDay)—Unstable anticoagulation predicts warfarin adverse effects regardless of time in therapeutic range, according to a study published online Sept. 2 in Circulation: Cardiovascular Quality and Ou ...

User comments