Review: A-fib risk up with oral, intravenous bisphosphonates

May 29, 2014
Review: A-fib risk up with oral, intravenous bisphosphonates

(HealthDay)—The risk of atrial fibrillation is increased with use of oral or intravenous bisphosphonates, with a greater risk seen for intravenous versus oral preparations, according to a review published in the June 1 issue of The American Journal of Cardiology.

Abhishek Sharma, M.D., from the Maimonides Medical Center in Brooklyn, N.Y., and colleagues conducted a systematic literature review to examine the incidence of new-onset with use of oral and intravenous . The final analyses included five randomized controlled trials (RCTs) and four , involving 135,347 individuals.

The researchers found observed a significantly increased risk of new-onset atrial fibrillation with intravenous and oral bisphosphonates (relative risks, 1.40 and 1.22, respectively). The risk of atrial fibrillation was higher with intravenous versus oral bisphosphonates, based on the z statistic (P = 0.03).

"In conclusion, pooled data from RCTs and observational studies suggest that risk of atrial fibrillation is increased by use of oral or intravenous bisphosphonates but further suggest that risk is relatively greater with intravenous preparations," the authors write.

Explore further: Female gender increases stroke risk in AF patients aged over 75 years by 20%

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

HRS: Bariatric surgery may prevent A-fib onset in obese

May 8, 2014

(HealthDay)—Bariatric surgery may prevent the development of atrial fibrillation in morbidly obese patients, according to research presented at the annual meeting of the Heart Rhythm Society, held from May 7 to 10 in San ...

Recommended for you

Female smokers face greatest risk for brain bleeds

July 21, 2016

Bleeding inside the lining of the brain (subarachnoid hemorrhage) is significantly more common among smokers, especially female smokers, than among people who do not smoke, according to new research in the American Heart ...

Global study shows stroke largely preventable

July 15, 2016

Ten risk factors that can be modified are responsible for nine of 10 strokes worldwide, but the ranking of those factors vary regionally, says a study led by researchers of the Population Health Research Institute (PHRI) ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.