Review: A-fib risk up with oral, intravenous bisphosphonates

Review: A-fib risk up with oral, intravenous bisphosphonates

(HealthDay)—The risk of atrial fibrillation is increased with use of oral or intravenous bisphosphonates, with a greater risk seen for intravenous versus oral preparations, according to a review published in the June 1 issue of The American Journal of Cardiology.

Abhishek Sharma, M.D., from the Maimonides Medical Center in Brooklyn, N.Y., and colleagues conducted a systematic literature review to examine the incidence of new-onset with use of oral and intravenous . The final analyses included five randomized controlled trials (RCTs) and four , involving 135,347 individuals.

The researchers found observed a significantly increased risk of new-onset atrial fibrillation with intravenous and oral bisphosphonates (relative risks, 1.40 and 1.22, respectively). The risk of atrial fibrillation was higher with intravenous versus oral bisphosphonates, based on the z statistic (P = 0.03).

"In conclusion, pooled data from RCTs and observational studies suggest that risk of atrial fibrillation is increased by use of oral or intravenous bisphosphonates but further suggest that risk is relatively greater with intravenous preparations," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

HRS: Bariatric surgery may prevent A-fib onset in obese

May 08, 2014

(HealthDay)—Bariatric surgery may prevent the development of atrial fibrillation in morbidly obese patients, according to research presented at the annual meeting of the Heart Rhythm Society, held from ...

Osteoporosis drug may be associated with irregular heartbeat

Apr 28, 2008

Alendronate, a medication used to prevent fractures in women with osteoporosis, may be associated with an increased risk of atrial fibrillation, a type of abnormal heart rhythm, according to a report in the April 28 issue ...

Recommended for you

Towards renal artery stenosis treatment

Aug 22, 2014

Renal artery stenting to open blockages in the kidney arteries may benefit patients who have historically been excluded from modern clinical trials, according to new recommendations for renal artery stenosis e-published in ...

New technologies help people with heart disease

Aug 22, 2014

People taking part in cardiac rehabilitation exercise programmes are likely to maintain healthy behaviours for longer with text message and web-based support, according to recent research from the University of Auckland.

A novel pathway for prevention of heart attack and stroke

Aug 21, 2014

A recent Finnish study could pave the way for preventing brain and cardiac ischemia induced by atherosclerosis. Finnish researchers have found that the low-expression variant of fatty acid-binding protein 4 (FABP4), which ...

User comments