Review: A-fib risk up with oral, intravenous bisphosphonates

Review: A-fib risk up with oral, intravenous bisphosphonates

(HealthDay)—The risk of atrial fibrillation is increased with use of oral or intravenous bisphosphonates, with a greater risk seen for intravenous versus oral preparations, according to a review published in the June 1 issue of The American Journal of Cardiology.

Abhishek Sharma, M.D., from the Maimonides Medical Center in Brooklyn, N.Y., and colleagues conducted a systematic literature review to examine the incidence of new-onset with use of oral and intravenous . The final analyses included five randomized controlled trials (RCTs) and four , involving 135,347 individuals.

The researchers found observed a significantly increased risk of new-onset atrial fibrillation with intravenous and oral bisphosphonates (relative risks, 1.40 and 1.22, respectively). The risk of atrial fibrillation was higher with intravenous versus oral bisphosphonates, based on the z statistic (P = 0.03).

"In conclusion, pooled data from RCTs and observational studies suggest that risk of atrial fibrillation is increased by use of oral or intravenous bisphosphonates but further suggest that risk is relatively greater with intravenous preparations," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

HRS: Bariatric surgery may prevent A-fib onset in obese

May 08, 2014

(HealthDay)—Bariatric surgery may prevent the development of atrial fibrillation in morbidly obese patients, according to research presented at the annual meeting of the Heart Rhythm Society, held from ...

Osteoporosis drug may be associated with irregular heartbeat

Apr 28, 2008

Alendronate, a medication used to prevent fractures in women with osteoporosis, may be associated with an increased risk of atrial fibrillation, a type of abnormal heart rhythm, according to a report in the April 28 issue ...

Recommended for you

Viagra protects the heart beyond the bedroom

19 hours ago

Viagra could be used as a safe treatment for heart disease, finds new research published today in the open access journal BMC Medicine. The study reveals that long-term daily treatment of Viagra can provide protection for th ...

User comments