Cognition affected in subgroups of breast cancer patients

Cognition affected in subgroups of breast cancer patients

(HealthDay)—Overall, cancer does not seem to affect pretreatment cognition in older women with breast cancer, compared to healthy controls; however, cognition may be affected in some subgroups of breast cancer patients, according to a study published online May 19 in the Journal of Clinical Oncology.

Jeanne S. Mandelblatt, M.D., M.P.H., from Georgetown University in Washington, D.C., and colleagues sought to determine if older patients with breast cancer have cognitive impairment before . Comparisons were made between newly-diagnosed nonmetastatic cancer patients and matched friend or community controls (age, >60 years) free from previous systemic treatment, dementia, or neurologic disease. Surveys and 17 neuropsychological tests were completed.

The researchers found that patients and controls had similar neuropsychological domains, but patients with stage II to III cancers had lower executive function compared with those with stage 0 to I disease, after adjustment (P = 0.05). Among older, nonwhite, less educated women, and those with greater comorbidity, the odds of impairment were significantly higher after adjustment. Comorbidity was strongly associated with impairment among patient cases (adjusted odds ratio, 8.77; P = 0.003), but not among controls (P = 0.97). Specifically, diabetes and cardiovascular disease were associated with impairment among patient cases.

"There were no overall differences between patients with and controls before systemic treatment, but there may be pretreatment within subgroups of patient cases with greater tumor or comorbidity burden," the authors write.

Several authors disclosed financial ties to the diagnostics and pharmaceutical industries.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Study shows epigenetic changes can drive cancer

3 hours ago

Cancer has long been thought to be primarily a genetic disease, but in recent decades scientists have come to believe that epigenetic changes – which don't change the DNA sequence but how it is 'read' – also play a role ...

Clearing cells to prevent cervical cancer

18 hours ago

A study published online in the International Journal of Cancer earlier this month describes a novel approach to preventing cervical cancer based on findings showing successful reduction in the risk of cervical cancer after ...

User comments