Insights into physiological mechanisms underlying symptoms of aging

Functional defect of autophagy- and SRF-dependent signaling regulate sarcopenia.

Toyohashi Tech researchers have proposed a new perspective on possible candidates of muscle aging, which contributes to develop effective supplements or pharmatheuticals to attenuate aging.

Sarcopenia refers to age-related loss of skeletal mass characterized by a deterioration of muscle quantity and quality, which leads to a gradual slowing of movement, a decline in strength and power, increased risk of fall-related injury, and often, frailty.

Several possible candidates for modulating sarcopenia have been proposed, however, the precise contribution of each is unknown.

Now, Kunihiro Sakuma and colleagues at Toyohashi Tech have published a review article on the age-related adaptation of positive and negative factors regulating sarcopenia in Pflügers Archiv - European Journal of Physiology, which is the oldest physiological journal in the world.

This review describes the positive regulators such as mTOR- and SRF-dependent signaling, which modulate protein syntesis and mRNA transcripiton to enhance muscle hypertrophy. In addition, the authors discuss major negative signaling (UPS, autophagy, myostatin-Smad, NF-kappaB) to elicit protein breakdown resulting in .

The report highlights the fact that autophagy-dependent signaling, and not the UPS system, is destroyed in sarcopenic muscle. Although the UPS system, an activator of protein degradation in various catabolic conditions (i.e., immobilization), is believed to elicit the atrophy of during aging, this review concludes there to be no contribution to this.

Advances in our understanding of sarcopenia have led to new approaches, such as supplements, and pharmatheuticals, to attenuate the symptoms.

More information: Kunihiro Sakuma, Wataru Aoi, and Akihiko Yamaguchi. "Current understanding of sarcopenia: possible candidates modulating muscle mass." European Journal of Physiology, Electrically published ahead of print (2014 May 7). DOI: 10.1007/s00424-014-1527-x

add to favorites email to friend print save as pdf

Related Stories

Knockout mouse grows larger, but weaker, muscles

Aug 15, 2013

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at ...

New possible target to combat muscle wasting

Apr 09, 2014

The pathological atrophy of skeletal muscle is a serious biomedical problem for which no effective treatment is currently available. The most affected populations are the elderly diagnosed with sarcopenia ...

Recommended for you

A better way to track emerging cell therapies using MRIs

Sep 19, 2014

Cellular therapeutics – using intact cells to treat and cure disease – is a hugely promising new approach in medicine but it is hindered by the inability of doctors and scientists to effectively track the movements, destination ...

User comments