Serum free light chain level increase precedes amyloidosis

Serum free light chain level increase precedes amyloidosis
Increased serum free light chains precede the presentation of immunoglobulin light chain amyloidosis, according to a study published online July 14 in the Journal of Clinical Oncology.

(HealthDay)—Increased serum free light chains (FLCs) precede the presentation of immunoglobulin light chain amyloidosis (AL amyloidosis), according to a study published online July 14 in the Journal of Clinical Oncology.

To characterize monoclonal immunoglobulin (M-Ig) light chains before clinical presentation of AL , Brendan M. Weiss, M.D., from the University of Pennsylvania in Philadelphia, and colleagues evaluated prediagnostic sera from 20 cases with AL amyloidosis and 20 healthy controls matched for age, sex, race, and age of serum sample. They performed serum protein electrophoresis with immunofixation and FLC analysis on all samples.

The researchers detected M-Ig in 100 percent of cases and none of the controls (P < 0.001). Detectable M-Ig was seen in 100 percent of cases at less than four years before diagnosis; 80 percent of cases at four to 11 years; and 42 percent of cases more than 11 years before diagnosis. At all time periods, the median FLC differential (FLC-diff) was higher in cases than controls. A FLC-diff >23 mg/L was seen in 85 percent of cases and no controls (P < 0.001). In 84 percent of cases and 16 percent of controls, the FLC-diff level increased more than 10 percent per year (P < 0.001).

"Increase of FLCs, including within the accepted normal range, precedes the development of AL amyloidosis for many years," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

Related Stories

Free light chains identified in chronic rhinosinusitis

date Jul 16, 2012

(HealthDay) -- Patients with chronic rhinosinusitis (CRS) have increased free light chain (FLC) concentrations, particularly those with CRS with nasal polyps (CRSwNP), according to a study published online ...

Drinking coffee, smoking may protect against cholangitis

date Jul 08, 2014

(HealthDay)—Coffee consumption and smoking might protect against the development of primary sclerosing cholangitis (PSC), according to a study published in the June issue of Clinical Gastroenterology an ...

Recommended for you

Nocturnal GERD tied to non-infectious rhinitis

date 16 hours ago

(HealthDay)—Nocturnal gastroesophageal reflux disease (GERD) appears to be a risk factor for non-infectious rhinitis (NIR), according to a study published online March 24 in Allergy.

COPD takes big toll on employment, mobility in US

date 20 hours ago

(HealthDay)—The respiratory illness known as COPD takes a toll on mobility and employment, with a new report finding that nearly one-quarter of Americans with the condition are unable to work.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.