Helmholtz Association of German Research Centres

New animal model gives insights into mechanisms of Parkinson's disease pathogenesis

In Parkinson's disease, the protein "alpha-synuclein" aggregates and accumulates within neurons. Specific areas of the brain become progressively affected as the disease develops and advances. The mechanism underlying this ...

Parkinson's & Movement disorders created 9 hours ago | popularity not rated yet | comments 0

Signs of motor disorders can appear years before disease manifestation

It is known that signs of neurological disorders such as Alzheimer's and Huntington's disease can appear years before the disease becomes manifest; these signs take the form of subtle changes in the brain and behavior of ...

Neuroscience created May 22, 2013 | popularity not rated yet | comments 0

Posttraumatic stress disorder associated with type 2 diabetes

The presence of posttraumatic stress disorder is significantly associated with the development of type 2 diabetes. This is the finding of scientists from the Helmholtz Zentrum München and the University Hospital Gießen ...

Psychology & Psychiatry created May 16, 2013 | popularity 5 / 5 (1) | comments 0

How individuality develops? Experience leads to the growth of new brain cells

How do organisms evolve into individuals that are distinguished from others by their own personal brain structure and behavior? Scientists in Dresden, Berlin, Münster, and Saarbrücken have now taken a decisive step towards ...

Neuroscience created May 09, 2013 | popularity 5 / 5 (9) | comments 0 | with audio podcast

Serotonin mediates exercise-induced generation of new neurons

Mice that exercise in running wheels exhibit increased neurogenesis in the brain. Crucial to this process is serotonin signaling. These are the findings of a study by researchers at the Max Delbrück Center ...

Neuroscience created May 13, 2013 | popularity 4.8 / 5 (4) | comments 0

Individual efficacy of chemotherapies

The function of the mitochondria – also defined as "power plants" within the cells – is essential as to whether, and how, some chemotherapeutic agents take effect in tissue. Scientists at the Helmholtz ...

Cancer created May 10, 2013 | popularity not rated yet | comments 0

Metastasis stem cells in the blood of breast cancer patients discovered

Individual cancer cells that break away from the original tumor and circulate through the blood stream are considered responsible for the development of metastases. These dreaded secondary tumors are the ...

Cancer created Apr 22, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Researchers find controlling element of Huntington's disease

A three molecule complex may be a target for treating Huntington's disease, a genetic disorder affecting the brain. This finding by an international research team including scientists from the German Center for Neurodegenerative ...

Diseases, Conditions, Syndromes created Feb 26, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast

'Healthier hormones' through diet and exercise

Weight loss—by dietary changes alone or combined with physical exercise—has a positive impact on the production of adipose tissue hormones: Adipose tissue produces less leptin but, instead, more adiponectin, which counteracts ...

Health created Mar 07, 2013 | popularity 3.5 / 5 (2) | comments 0 | with audio podcast

Evolution in the antibody factory: How immune cells are able to advance their own evolution

Immune system B cells play a crucial role in the defence of pathogens; when they detect such an intruder, they produce antibodies that help to combat the enemy. They concurrently and continuously improve ...

Immunology created Mar 11, 2013 | popularity 4.7 / 5 (3) | comments 0 | with audio podcast

Misplaced molecules: New insights into the causes of dementia

A team of German and Belgian researchers has succeeded in gaining new insights into the causes of certain movement disorders and forms of dementia. Scientists including Bettina Schmid and Christian Haass from the German Center ...

Neuroscience created Mar 01, 2013 | popularity 3.7 / 5 (3) | comments 0 | with audio podcast

GI tract bacteria may protect against autoimmune disease

Early life exposure to normal bacteria of the GI tract (gut microbes) protects against autoimmune disease in mice, according to research published on-line in the January 17 edition of Science. The study ...

Immunology created Jan 17, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Translation error tracked in the brain of dementia patients

In certain dementias silent areas of the genetic code are translated into highly unusual proteins by mistake. An international team of scientists including researchers from the German Center for Neurodegenerative ...

Neuroscience created Feb 07, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Exposure to everyday noise influences heart rate variability

(Medical Xpress)—Exposure to noise, for example from road traffic, may adversely affect the cardiovascular system. Until now, underlying mechanisms linking noise to elevated cardiovascular risk have rarely been explored ...

Health created May 02, 2013 | popularity not rated yet | comments 0

The molecular basis of touch sensation: New function of a well-known gene identified

A gene known to control lens development in mice and humans is also crucial for the development of neurons responsible for mechanosensory function, as neurobiologists of the Max Delbrück Center for Molecular Medicine ...

Genetics created Feb 21, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast