Antibody-secreting plasma cells arise from B cell precursors and are essential for adaptive immune responses against invading pathogens. Plasma cell dysfunction is associated with autoimmune and neoplastic disorders, including ...
Mar 17, 2016
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Bladder cancer is the fourth most common cancer among men in the United States. While low-grade tumors have a very favorable prognosis, muscle-invasive and metastatic tumors have poorer survival rates.
Mar 17, 2016
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Individuals with 2p15p16.1 microdeletion syndrome present with intellectual disability, microcephaly, delayed growth, dysmorphic craniofacial features, and digital abnormalities. The precise genetic region responsible for ...
Mar 17, 2016
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Preeclampsia is characterized by elevated blood pressure in the second half of pregnancy and impaired blood flow to the placenta, which increases the risk of premature birth and pregnancy complications.
Mar 17, 2016
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Acute myeloid leukemia (AML) is a cancer of myeloid stem cells that develops in both adult and pediatric populations. Mutations that cause hyperactivation of the FMS-like tyrosine kinase 3 (FLT3) are commonly found in AML, ...
Mar 17, 2016
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Individuals infected with HIV exhibit both severe immune deficiency and aberrant inflammation, resulting in susceptibility to secondary infection as the disease progresses. HIV-associated deficiencies in adaptive immune responses ...
Mar 17, 2016
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β cells in pancreatic islets are responsible for producing insulin, which is essential to regulate blood glucose homeostasis. In type 1 diabetes, pancreatic β cells are destroyed due to an autoimmune attack, whereas in ...
Mar 17, 2016
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Lymphatic vessels play multifaceted roles in the body, including the absorption of dietary lipid in the intestines as well as the movement of immune cells throughout the body. Previous work by Guillermo Oliver and colleagues ...
Feb 25, 2016
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In cardiac hypertrophy, metabolic energy reserves in the heart are depleted, which is thought to contribute to the subsequent development of heart failure. The primary energy source in the heart relies on fatty acid oxidation ...
Feb 25, 2016
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The central nervous system is inaccessible for many types of therapeutics because of the blood brain barrier, a highly selective membrane that protects the brain from bacterial infection and other substances. An alternative ...
Feb 25, 2016
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