Diabetes

Fractalkine: New protein target for controlling diabetes

Researchers at the University of California, San Diego School of Medicine have identified a previously unknown biological mechanism involved in the regulation of pancreatic islet beta cells, whose role is to produce and release ...

Medical research

Scientists identify cell death pathway involved in lethal sepsis

Sepsis, a form of systemic inflammation, is the leading cause of death in critically ill patients. Sepsis is linked with massive cell death; however, the specific mechanisms involved in the lethality of sepsis are unclear. ...

Immunology

Insights into a versatile molecular death switch

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard healthy and functioning ...

Oncology & Cancer

Two-pronged attack on chemotherapy-resistant leukemia cells

Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer in Switzerland. Despite intensive chemotherapy, one fifth of the patients suffer a relapse, which usually goes hand in hand with a poor prognosis. ...

Immunology

Sensitive balance in the immune system

Apoptosis is used by cells that are changed by disease or are simply not needed any longer to eliminate themselves before they become a hazard to the body—on a cellular level, death is part of life. Disruption of this process ...

Genetics

Cellular suicide switch discovered

A newly discovered early-warning system triggers cellular suicide when a critical RNA editing system breaks down.

Genetics

Why does making new egg cells require so much cell death?

A highly detailed study of how the roundworm C. elegans forms oocytes suggests that the egg-making process leads to the formation and subsequent destruction of cells with an extra nucleus, but that some cellular materials ...

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