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Scientists improve arthritis treatments: Rheumatism patients can hope for a new therapy

Together with colleagues from the international rheumatic diseases research community, scientists of the Charité – Universitätsmedizin Berlin have presented a new therapy approach for the treatment of rheumatoid arthritis ...

Arthritis & Rheumatism created Feb 14, 2013 | popularity 5 / 5 (1) | comments 0

Study finds potential to match tumors with known cancer drugs

When it comes to gene sequencing and personalized medicine for cancer, spotting an aberrant kinase is a home run. The proteins are relatively easy to target with drugs and plenty of kinase inhibitors already exist.

Cancer created Feb 05, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Gleevec's latest approval is for pediatric cancer

(HealthDay)—The anti-cancer drug Gleevec (imatinib) has received new U.S. Food and Drug Administration approval to treat the most common type of pediatric cancer, affecting some 2,900 children each year, the agency said ...

Cancer created Jan 25, 2013 | popularity not rated yet | comments 0

Treatment targeting PI3K may delay resistance to anti-HER2 therapy in breast cancer patients

Patients with HER2-positive breast cancer being treated with anti-HER2 therapy may be able to prevent or delay resistance to the therapy with the addition of a phosphatidylinositol-3 kinase inhibitor to their treatment regimens.

Cancer created Jan 23, 2013 | popularity not rated yet | comments 0

Drug targets hard-to-reach leukemia stem cells responsible for relapses

Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms ...

Cancer created Jan 17, 2013 | popularity 3.7 / 5 (3) | comments 0 | with audio podcast

Trapping malaria parasites inside host cell basis for new drugs

One of the most insidious ways that parasitic diseases such as malaria and toxoplasmosis wreak their havoc is by hijacking their host's natural cellular processes, turning self against self. Researchers from ...

Medical research created Jan 16, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

EGFR mutation not prognostic factor in non-small cell lung cancer

Recent studies have demonstrated that molecular-targeted agents, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), may prolong survival of selected patients based on tumor biomarkers. The presence ...

Cancer created Jan 15, 2013 | popularity not rated yet | comments 0

Patients with EGFR exon 20 insertions have poorer prognosis

Exon 20 insertions are the third most common family of epidermal growth factor receptor (EGFR) mutations found in non–small-cell lung cancer (NSCLC). Little is known about cancers harboring these mutations aside from their ...

Cancer created Jan 15, 2013 | popularity not rated yet | comments 0

Discovery promises to improve drugs used to fight cancer, other diseases

(Medical Xpress)—Even when at rest, the human body is a flurry of activity. Like a microscopic metropolis locked in a state of perpetual rush hour traffic, the trillions of cells that make us who we are work feverishly ...

Medical research created Jan 11, 2013 | popularity 4.3 / 5 (3) | comments 0 | with audio podcast

Cellular fuel gauge may hold the key to restricting cancer growth

Researchers at McGill University have discovered that a key regulator of energy metabolism in cancer cells known as the AMP-activated protein kinase (AMPK) may play a crucial role in restricting cancer cell growth. AMPK acts ...

Cancer created Dec 27, 2012 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia

An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning ...

Cancer created Dec 24, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Options increase for CML patients failed by existing drugs

The U.S. Food and Drug Administration (FDA) this month expanded the options for patients with chronic myeloid leukemia and one form of acute lymphoblastic leukemia that carries the Philadelphia chromosome (Ph+ALL). It approved ...

Cancer created Dec 21, 2012 | popularity not rated yet | comments 0

Protein kinase Akt identified as arbiter of cancer stem cell fate, paper reports

(Medical Xpress)—The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death. New work on Akt's role in cancer stem cell biology from the lab of senior author ...

Cancer created Dec 20, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Neurons die in Alzheimer's because of faulty cell cycle control before plaques and tangles appear

The two infamous proteins, amyloid-beta (Aβ) and tau, that characterize advanced Alzheimer's disease (AD), start healthy neurons on the road to cell death long before the appearance of the deadly plaques and tangles by working ...

Alzheimer's disease & dementia created Dec 17, 2012 | popularity 5 / 5 (1) | comments 0

Ibrutinib has 'unprecedented' impact on mantle cell lymphoma

An international study of ibrutinib in people with relapsed or refractory mantle cell lymphoma (MCL) continues to show unprecedented and durable results with few side effects.

Cancer created Dec 14, 2012 | popularity not rated yet | comments 0