Making it easier to make stem cells
The process researchers use to generate induced pluripotent stem cells (iPSCs)—a special type of stem cell that can be made in the lab from any type of adult cell—is time consuming and inefficient. To ...
Medical research
Sep 25, 2012 |
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Scientists discover mevalonate kinase gene mutations associated with disseminated superficial actinic porokeratosis
A Chinese research team, led by Anhui Medical University and BGI, has found the strong genetic evidences of mevalonate kinase gene (MVK) mutations link to disseminated superficial actinic porokeratosis (DSAP). It is a major ...
Genetics
Sep 16, 2012 |
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Study: Common gene mutation affects kids with autism spectrum disorders
(Medical Xpress)—Over the past decade, researchers have made great strides in identifying genes that lead to an increased risk of autism spectrum disorders (ASD), which result in a continuum of social deficits, communication ...
Autism spectrum disorders
Sep 14, 2012 |
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Charting the SH2 pool
New research published in BioMed Central's open access journal Cell Communication and Signaling describes a large set of interactions (interactome) which maps the range of phosphotyrosine (pTyr)-dependent interactions with S ...
Medical research
Sep 13, 2012 |
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Researchers identify possible new oncogene and future therapy target
A gene that may possibly belong to an entire new family of oncogenes has been linked by researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) to the resistance ...
Cancer
Sep 11, 2012 |
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Crizotinib reduces tumor size in patients with ALK positive lung cancer
Crizotinib is effective in shrinking tumors in patients with anaplastic lymphoma receptor tyrosine kinase (ALK) positive non-small cell lung cancer, a cancer commonly found in people who never smoked, and should be the standard ...
Cancer
Sep 06, 2012 |
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Mathematical modelling to tackle metabolic diseases
Predictive mathematical models of signalling pathways are powerful biological tools that could be used for drug development. Using a similar approach, European scientists developed a computational model for ...
Medical research
Aug 30, 2012 |
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Metabolic protein wields phosphate group to activate cancer-promoting genes
A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson ...
Cancer
Aug 16, 2012 |
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Vandetanib almost doubles progression free survival in patients with thyroid cancer
Results of a phase 2 randomised trial for patients with advanced differentiated thyroid cancer (DTC) show that those treated with the oral targeted agent vandetanib survived without the disease getting worse for almost twice ...
Cancer
Aug 13, 2012 |
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New class of proteins allows breast cancer cells to evade tyrosine kinase inhibitors
Aberrant regulation of cell growth pathways is required for normal cells to become cancerous, and in many types of cancer, cell growth is driven by a group of enzymes known as receptor tyrosine kinases (RTKs). The RTK epidermal ...
Cancer
Aug 13, 2012 |
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A genetic variation common in East Asian populations has been linked to cancer drug resistance
Tyrosine kinase inhibitors (TKIs) kill cancerous cells by inducing programmed cell death. They are of enormous therapeutic benefit to patients with chronic myeloid leukemia (CML) and certain types of lung ...
Genetics
Aug 02, 2012 |
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Discovery explains how cellular pathways converge to regulate food intake and body weight
In the complex chain of molecular events that underlie eating behaviors and body weight, the AMP-activated protein kinase (AMPK) enzyme has proven to be a critical link.
Medical research
Jul 03, 2012 |
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Researchers identify protein required to regrow injured nerves in limbs
A protein required to regrow injured peripheral nerves has been identified by researchers at Washington University School of Medicine in St. Louis.
Neuroscience
Jun 20, 2012 |
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Regenerated cells may restore vision after corneal dysfunction
Regenerative medicine, or the use of specially grown tissues and cells to treat injuries and diseases, has been successful in treating disorders of a number of organs, including heart, pancreas, and cartilage. ...
Ophthalmology
Jun 14, 2012 |
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When being scared twice is enough to remember
One of the brain's jobs is to help us figure out what's important enough to be remembered. Scientists at Yerkes National Primate Research Center, Emory University have achieved some insight into how fleeting experiences become ...
Neuroscience
Jun 12, 2012 |
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