Archive: 02/08/2017

Review: Levetiracetam best monotherapy for partial seizures

(HealthDay)—Levetiracetam performs better than carbamazepine and lamotrigine for individuals with partial seizures, according to a review and meta-analysis published online June 29 in the Cochrane Library.

Aug 2, 2017

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Three Klebsiella species cause life-threatening infections and share drug resistance genes

A team of US researchers has discovered that three different species of Klebsiella bacteria can cause life-threatening infections in hospital patients and that all three share genes that confer resistance to the most commonly ...

Aug 2, 2017

Good cellular neighbors combat incipient cancers

Scientists have spent decades studying the nature of tumor cells, but few have looked to see what was happening in the surrounding tissue.

Aug 2, 2017

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Comprehensive sequencing program shows promise of precision medicine for advanced cancer

The average metastatic cancer has more genetic mutations than are seen in early stage tumors, a new study finds.

Aug 2, 2017

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Inappropriate med use high in cognitively impaired seniors

(HealthDay)—Many nursing home residents with cognitive impairment or dementia have potentially inappropriate medication (PIM) use, with PIM use more likely among frail individuals, according to a study published online ...

Aug 2, 2017

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TXNIP blocks autophagic flux, causes alpha-synuclein accumulation

(HealthDay)—Thioredoxin-interacting protein (TXNIP) blocks autophagic flux and induces expression of α-synuclein accumulation via inhibition of ATP13A2, according to a study published online July 29 in CNS Neuroscience ...

Aug 2, 2017

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ABP 501, adalimumab biosimilar, safe and effective, for psoriasis

(HealthDay)—The biosimilar ABP 501 has similar clinical efficacy and safety to adalimumab for the treatment of moderate-to-severe plaque psoriasis, according to a study published online July 28 in the British Journal of ...

Aug 2, 2017

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Canagliflozin delays increase in certain CV biomarkers in T2DM

(HealthDay)—For patients with type 2 diabetes mellitus (T2DM), treatment with canagliflozin delays the increase in serum N-terminal pro-B type natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (hsTnI) compared ...

Aug 2, 2017

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Mechanisms ID'd for curcumin resensitization of cancer cells

(HealthDay)—Curcumin can resensitize chemoresistant pancreatic ductal adenocarcinoma (PDAC) cells through inhibition of the polycomb repressive complex 2 (PRC2)-PVT1-c-Myc axis, according to a study published online July ...

Aug 2, 2017

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Similar defects ID'd for T2DM, chronic pancreatitis and diabetes

(HealthDay)—Patients with type 2 diabetes and those with diabetes secondary to chronic pancreatitis have similarly impaired α-cell responses to oral glucose ingestion and hypoglycemia, according to a study published online ...

Aug 2, 2017

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