Archive: 31/03/2016

Protease-activated receptors differentially regulate endothelial nitric oxide synthase

Protease-activated receptors (PARs) are a family of G-protein-coupled receptors that are primarily expressed in cells of the vasculature and known for their involvement in regulation of vascular tone. These receptors induce ...

Mar 31, 2016

Zika virus structure revealed, a critical advance in the development of treatments

A team led by Purdue University researchers is the first to determine the structure of the Zika virus, which reveals insights critical to the development of effective antiviral treatments and vaccines.

Mar 31, 2016

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Reactivation of HSV described in patient after cataract surgery

(HealthDay)—In a letter to the editor published online March 24 in Clinical & Experimental Ophthalmology, a case of reactivation of herpes simplex virus (HSV) uveitis is described in a patient with unexplained persistent ...

Mar 31, 2016

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Study reveals the possibility of curbing synapse loss in Alzheimer's

Researchers at Boston Children's Hospital show how brain connections, or synapses, are lost early in Alzheimer's disease and demonstrate that the process starts—and could potentially be halted—before telltale plaques ...

Mar 31, 2016

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Fights are won and lost in the brain

Researchers at the RIKEN Brain Science Institute in Japan have found that a deep-brain structure called the habenula contains two neural circuits that work in a complex interplay to influence whether a fight will be a win ...

Mar 31, 2016

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Study discovers link between celiac disease risk and a noncoding RNA

Researchers have identified a common variant in a non-coding RNA that may contribute to the intestinal inflammation that occurs in people with celiac disease. The findings point to a possible new risk factor for developing ...

Mar 31, 2016

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Cold-adapted attenuated polio virus—towards a post-eradication vaccine

With only 74 cases reported worldwide in 2015, poliomyelitis eradication is in sight. However, polio vaccines will be required for the foreseeable future to prevent re-emergence of the disease, and such vaccines need to be ...

Mar 31, 2016

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Hepatitis C virus uses Netrin-1 to hijack host cells

Hepatitis C virus (HCV) is a small, enveloped virus comprising an RNA genome encased in a protein capsid and surrounded by a lipid bilayer containing two glycoproteins. Acute infection can cause hepatitis but the virus usually ...

Mar 31, 2016

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Non-surgical management of rectal cancer increasing

(HealthDay)—Use of nonoperative management (NOM) of rectal cancer is increasing, but primarily in disadvantaged patients, according to a study published online March 28 in the Journal of Clinical Oncology.

Mar 31, 2016

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Neuronal heparan sulfates play role in amyloid pathology

(HealthDay)—Neuronal heparan sulfates (HSs) modulate brain amyloid-β (Aβ) clearance and aggregation in a mouse model of Alzheimer's disease (AD), according to an experimental study published in the March 30 issue of Science ...

Mar 31, 2016

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