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Oncology & Cancer news
Oncology & Cancer
Single-cell atlas reveals hidden patterns of differentiation in acute myeloid leukemia
Princess Margaret Cancer Center at University Health Network-led researchers constructed a detailed single-cell atlas of human blood development, improving understanding of leukemia formation and enabling a more precise classification ...
16 hours ago
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Oncology & Cancer
Single DNA mutation disrupts key tumor-suppressing pathways, elevating blood cancer risk
Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key tumor-suppressing pathways, opening up new avenues for blood cancer treatment.
15 hours ago
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Black and Hispanic children with high-risk neuroblastoma have worse outcomes despite standardized treatment
Black and Hispanic children with high-risk neuroblastoma experience worse survival outcomes than their white peers, even when treated in frontline clinical trials, according to a study led by a UT Southwestern Medical Center ...
15 hours ago
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PBAF chromatin may explain melanoma spread to the brain
Scientists at the Icahn School of Medicine at Mount Sinai have discovered a possible reason why some cases of melanoma—a dangerous form of skin cancer—spread to the brain. Their study, published in Molecular Cell, highlights ...
12 hours ago
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Old drug, new tricks: Why an anti-psychotic could help treat brain cancer
New research from SAHMRI and Flinders University has shed light on how the decades-old antipsychotic drug, trifluoperazine (TFP), works against glioblastoma (GBM), the most aggressive form of brain cancer.
17 hours ago
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Identifying noncancer risks among Japanese female breast cancer survivors
Breast cancer is the most common cancer among women in several countries around the world, including Japan, where 1 in 9 women has the risk of developing the disease. In recent years, early detection and advancements in treatment ...
16 hours ago
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'Game-changer' clinical trial launches for Australia's second-deadliest cancer
A world-first clinical trial launched in Melbourne is being hailed as a "game-changer" for its potential to revolutionize the way people with bowel cancer are treated.
18 hours ago
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Lower screening age calls for more tailored bowel cancer surveillance
Australia's recent move to lower the starting age for bowel (colorectal) cancer screening from 50 down to 45 years old will mean better outcomes—but it will also increase the burden on an already struggling health care ...
16 hours ago
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Universal screening approach achieves a comparable detection rate of lung cancer
Research led by Professors Jianxing He and Wenhua Liang from the First Affiliated Hospital of Guangzhou Medical University and the National Clinical Research Center for Respiratory Disease, focusing on lung cancer screening ...
17 hours ago
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Novel CAR-T therapy achieves positive results in a high proportion of patients with a refractory type of lymphoma
Researchers from the Sant Pau Research Institute (IR Sant Pau), in collaboration with Sant Pau Hospital and the Josep Carreras Leukemia Research Institute, have developed an innovative CAR-T cell therapy targeting the CD30 ...
Apr 29, 2025
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Computational analysis clarifies cancer risk for families with genetic variants
QIMR Berghofer-led research has shown that new advanced computational prediction tools can improve the accuracy of genetic testing for families affected by an inherited condition that significantly increases their risk of ...
Apr 29, 2025
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Exercise can counter detrimental effects of cancer treatment, review suggests
Exercise can counter the detrimental effects of cancer treatment, such as heart and nerve damage and brain fog, suggests an overarching review of the existing pooled data analyses of the most recent research, published online ...
Apr 29, 2025
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Surviving cancer, still suffering: Survey reveals gaps in follow‑up care
More Americans are beating cancer than ever, yet many still grapple with treatment's long shadow—especially on their mental health.
Apr 29, 2025
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Genetic-based tool helps determine if surgery is a good option for pancreatic cancer patients
Researchers in Japan have developed a predictive model that could improve treatment decisions for advanced pancreatic cancer patients. By combining tumor marker readings with patients' genetic information, their model predicts ...
Apr 29, 2025
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A liquid biopsy-based assay could detect recurrence prior to imaging in patients with resectable colorectal cancer
An ultrasensitive circulating tumor DNA (ctDNA)-based liquid biopsy assay detected signs of recurrence prior to imaging and provided prognostic value within one month after surgery in patients with colorectal cancer (CRC), ...
Apr 29, 2025
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Adjuvant PD-1 blockade for mismatch repair-deficient solid cancers directed by ctDNA status delivers clinical benefit
Pembrolizumab (Keytruda), an anti-PD-1 antibody, cleared minimal residual disease and protected against recurrence in patients with DNA mismatch repair-deficient (dMMR) early-stage solid cancers who had detectable circulating ...
Apr 29, 2025
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AI-driven analysis of digital pathology images may improve pediatric sarcoma subtyping
An artificial intelligence (AI)-based model accurately classified pediatric sarcomas using digital pathology images alone, according to results presented at the American Association for Cancer Research (AACR) Annual Meeting, ...
Apr 29, 2025
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Pregnancy-related proteins in tumors linked to worse survival in female lung cancer patients
Lung cancer can co-opt genes that normally help a fetus develop and evade the mother's immune system. And while these pregnancy-specific glycoproteins (PSGs) can get activated in the cancers of both men and women, female ...
Apr 29, 2025
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Prostate cancer therapies: AI-based image analysis detects early organ damage
A research team at the Technical University of Munich (TUM) has developed a method to predict early-stage kidney damage caused by certain cancer treatments. The kidneys begin to shrink slightly—months before any measurable ...
Apr 29, 2025
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3D cell cultures provide new insights on lung cancer treatment response
Researchers have shown that activation of the protein YAP, known to help cancer cells survive treatment, behaves very differently in cell culture models depending on how they are grown in the lab, highlighting the importance ...
Apr 29, 2025
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New study highlights success of financial toxicity tumor board in reducing cancer treatment costs
Financial toxicity, the financial distress linked to cancer treatment, significantly impacts patient outcomes. To combat this, the Atrium Health Levine Cancer Institute established a Financial Toxicity Tumor Board in 2019.
Apr 29, 2025
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AI-based liquid biopsy shows promise for detecting brain cancer
A new liquid biopsy approach developed by Johns Hopkins Kimmel Cancer Center investigators could revolutionize brain cancer detection by identifying circulating DNA fragments from tumors and immune cells in blood samples, ...
Apr 29, 2025
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Stage 0 cancer is often overlooked, but it could be your earliest warning sign
At 71, Tina Knowles—the fashion designer, businesswoman, and mother of Beyoncé—made headlines not for her career, but for a deeply personal revelation: her breast cancer diagnosis. In 2023, a routine mammogram uncovered ...
Apr 29, 2025
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Drug combination inhibits genes that drive aggressive pancreatic cancer, study finds
HonorHealth Research Institute's new downtown Phoenix laboratory has produced its first study, centered on a promising new treatment for pancreatic cancer, one of the most aggressive and difficult to treat of all malignancies.
Apr 29, 2025
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AACR: New CAR T cell therapy benefits patients with advanced thyroid cancers
A new chimeric antigen receptor (CAR) T cell therapy called AIC100, which targets the ICAM-1 protein, demonstrated encouraging responses and an acceptable safety profile in patients with two types of advanced thyroid cancer, ...
Apr 29, 2025
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