Scientists unveil surprising human vs. mouse differences in a major cancer immunotherapy target
Since its discovery in the 1990s, programmed cell death protein 1 (PD-1) has been regarded as a leading target in cancer treatments. A checkpoint receptor that often resides on the surface of immune system cells, the PD-1 ...
Jan 3, 2025
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Advanced imaging uncovers hidden metastases in high-risk prostate cancer cases
A study led by researchers at the UCLA Health Jonsson Comprehensive Cancer Center has found that many cases of high-risk nonmetastatic hormone-sensitive prostate cancer may be more advanced than previously thought.
Jan 3, 2025
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Mini-tumors from circulating breast cancer cells offer new treatment insights
Tumor cells circulating in the blood are the germ cells of breast cancer metastases. They are very rare and have not been propagated in the culture dish until now, which made research into therapy resistance difficult.
Jan 3, 2025
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Surprising 'two-faced' cancer gene role supports paradigm shift in predicting disease
A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer. This unexpected discovery could help ...
Jan 3, 2025
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FDA approves subcutaneous opdivo qvantig for most solid tumor indications
The U.S. Food and Drug Administration has approved Opdivo Qvantig (nivolumab and hyaluronidase-nvhy) injection for subcutaneous use for most previously approved adult, solid tumor Opdivo (nivolumab) indications.
Jan 3, 2025
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Improving predictions about brain cancer outcomes with the right imaging criteria
A paper published in the Journal of Clinical Oncology, titled "Comparative Analysis of Intracranial Response Assessment Criteria in Patients With Melanoma Brain Metastases Treated With Combination Nivolumab + Ipilimumab in ...
Jan 3, 2025
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New guidelines for managing blood cancers in pregnancy
A new set of guidelines has been developed to assist with the diagnosis and expert management of serious blood cancers in pregnancy.
Jan 3, 2025
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Mitochondrial DNA plays an underappreciated role in leukemia development
Mitochondria are vital to energy production in cells and so play a key role in fueling cancer growth. However, how mitochondrial DNA (mtDNA) contributes to cancer has been unclear.
Jan 2, 2025
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A 'ticking time bomb' for liver cancer: Liver cells' self-defense mechanism against cancer may backfire
Scientists at University of California San Diego School of Medicine have shed new light on the development of liver cancer, the sixth most frequently diagnosed cancer and fourth leading cause of cancer deaths worldwide.
Jan 2, 2025
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Researchers reveal why the lung is a frequent site of cancer metastasis
More than half of cancer patients in whom the cancer spreads beyond the primary site have lung metastases. What makes the lungs such a tempting place for cancer cells?
Jan 2, 2025
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Discovery of CAR-T 'memory cells' could boost cancer therapy
Researchers at the University of Colorado Anschutz Medical Campus have discovered that some CAR-T cells engineered to fight cancer and other conditions carry the memory of past encounters with bacteria, viruses and other ...
Jan 2, 2025
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AI-based ultrasound evaluation can improve ovarian cancer diagnoses
A new international study led by researchers at Karolinska Institutet in Sweden shows that AI-based models can outperform human experts at identifying ovarian cancer in ultrasound images. The study is published in Nature ...
Jan 2, 2025
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Open-access resource simplifies cancer subtype classification for researchers
A multi-institutional team of scientists has developed a free, publicly accessible resource to aid in classification of patient tumor samples based on distinct molecular features identified by The Cancer Genome Atlas (TCGA) ...
Jan 2, 2025
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A new weapon in the battle against cancer: The story of combo prodrug TTFA-Platin
Cancer is a deadly disease taking the lives of thousands of people worldwide, and researchers are constantly looking for better alternatives for treatment. One of the major breakthroughs is combination therapy—a treatment ...
Enzyme discovery sheds light on pancreatic cancer's deadly spread
Pancreatic cancer kills 50,000 people each year, according to the National Cancer Institute, and there are few effective treatment options for the disease. In a new study, researchers at University of California San Diego ...
Jan 2, 2025
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Researchers find potential link between nuclear speckles patterns and cancer treatment outcomes
Fighting cancer can seem like a deadly game of chance. While some patients may respond well to certain treatments, others might not be as fortunate. Doctors and scientists have long struggled to explain why. Now, Cold Spring ...
Jan 2, 2025
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Patients with heart disease may be at increased risk for advanced breast cancer
Cardiovascular disease (CVD) and cancer are the two leading causes of death in the U.S. According to researchers from The University of Texas MD Anderson Cancer Center, patients diagnosed with late-stage or metastatic breast ...
Jan 2, 2025
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Clinical trial shows cancer-preventing topical immunotherapy trains immune system to fight precancers
A new study by investigators from Mass General Brigham uncovers how a novel immunotherapy prevents squamous cell carcinoma, with benefits lasting five years after treatment. This therapy is the first to activate specific ...
Jan 2, 2025
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Palliative care offers additional help during cancer treatment
When facing a cancer diagnosis, patients often hear the term "palliative care" but may not fully understand what it means. Palliative care is all about improving quality of life and providing patients with an extra layer ...
Jan 2, 2025
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40 years of research into genetic causes of childhood and adolescent cancers
Cancer in children and adolescents is rare. Nevertheless, malignant diseases are still one of the most common causes of death in this age group. Survivors of childhood or adolescent cancer often suffer chronic health problems ...
Dec 30, 2024
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Oleanolic acid from grapes may increase chemotherapy effectiveness
Researchers describe a new potential role for oleanic acid as a modulator of the DNA damage response following camptothecin treatment. Administration of oleanic acid in combination with camptothecin for cancer chemotherapy ...
Dec 30, 2024
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What you should know about pancreatic cancer screening
Pancreatic cancer screening has advanced significantly in recent years. There are now research-based guidelines on screening for people at high risk of developing the disease, and researchers are collaborating to develop ...
Dec 29, 2024
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We don't all need regular skin cancer screening—but you can know your risk and check yourself
Australia has one of the highest skin cancer rates globally, with nearly 19,000 Australians diagnosed with invasive melanoma—the most lethal type of skin cancer—each year.
Dec 28, 2024
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