Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to efficiently activate innate immunity while avoiding its overactivation. ...
Feb 18, 2025
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Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal cord compression. This ...
Feb 14, 2025
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Ischemic heart disease is the most common cause of death in the world. It begins with a heart attack, also known as a myocardial infarction (MI), which causes part of the heart to die due to inadequate coronary blood flow. ...
Aug 29, 2024
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A new study reveals that aging human pancreatic beta cells display features of senescence while maintaining elevated levels of genes crucial for their function. Despite their aging status, these cells therefore exhibit an ...
Jun 4, 2024
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Why are severe courses of SARS-CoV-2 infection much less common in children and adolescents than in adults? Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered that ...
Oct 18, 2023
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Depression is a common mental health problem that affects people across demographics. Scientists have long known that there may be a genetic component that confers predisposition to depression, but the specific underlying ...
Sep 7, 2023
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People with Down syndrome, the condition caused by an extra copy of chromosome 21, or trisomy 21, display chronic dysregulation of their immune system, which can contribute to high rates of autoimmune conditions and severe ...
Jul 17, 2023
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Infants born with Down syndrome, the genetic condition caused by an extra copy of chromosome 21, or trisomy 21, are highly predisposed to congenital heart defects. It is estimated that nearly half of newborns with Down syndrome ...
Jun 21, 2023
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People with Down syndrome, or trisomy 21, a genetic condition caused by an extra copy of human chromosome 21, experienced a remarkable increase in life expectancy during the 20th century. In the early 1900s, less than 20% ...
Jun 6, 2023
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The entire family of coronaviruses is equipped with multiple methods of evading the human immune system, and two new studies have taken a deep dive into how these viruses, including SARS-CoV-2, leverage highly specialized ...
